Results 61 to 70 of about 17,239,575 (269)

Happiness as an end: a critique of Aristotle’s rational eudaemonism

open access: yesInkanyiso, 2018
This paper examines Aristotle’s concept of happiness as encapsulated in his Nicomachean Ethics. Aristotle argues that happiness is the supreme practical good because it is perfect, final, self-sufficing and complete in itself.
Edward U. Ezedike
doaj   +1 more source

Tacotron: Towards End-to-End Speech Synthesis

open access: yes, 2017
A text-to-speech synthesis system typically consists of multiple stages, such as a text analysis frontend, an acoustic model and an audio synthesis module. Building these components often requires extensive domain expertise and may contain brittle design
Agiomyrgiannakis, Yannis   +13 more
core   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack   +12 more
wiley   +1 more source

Modeling transcriptomic age using knowledge-primed artificial neural networks

open access: yesnpj Aging and Mechanisms of Disease, 2021
The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. However, beyond their
Nicholas Holzscheck   +12 more
doaj   +1 more source

Query-guided End-to-End Person Search

open access: yes, 2019
Person search has recently gained attention as the novel task of finding a person, provided as a cropped sample, from a gallery of non-cropped images, whereby several other people are also visible. We believe that i.
Amin, Sikandar   +3 more
core   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell   +14 more
wiley   +1 more source

Miniature modular microwave end-to-end receiver [PDF]

open access: yes, 1993
An end-to-end microwave receiver system contained in a single miniature hybrid package mounted on a single heatsink is presented. It includes an input end connected to a microwave receiver antenna and an output end which produces a digital count ...
Cooley, Thomas W.   +3 more
core   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher   +8 more
wiley   +1 more source

A Reply to John Dudley on Aristotle, Physics 2.5, 196b17–21

open access: yesPeitho, 2017
In this article, I restate the interpretation of Aristotle’s Ph. 2.5, 196b17– 21, which I presented for the first time in my book I fondamenti della causalità naturale (2006).
Giovanna R. Giardina
doaj   +1 more source

A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR)

open access: yesBeilstein Journal of Organic Chemistry, 2020
Systems glycobiology aims to provide models and analysis tools that account for the biosynthesis, regulation, and interactions with glycoconjugates.
Benjamin P. Kellman   +19 more
doaj   +1 more source

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