Results 81 to 90 of about 7,379,857 (314)
Modeling transcriptomic age using knowledge-primed artificial neural networks
npj Aging and Mechanisms of Disease, 2021 The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. However, beyond their
Nicholas Holzscheck +12 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Reply to John Dudley on Aristotle, Physics 2.5, 196b17–21
Peitho, 2017 In this article, I restate the interpretation of Aristotle’s Ph. 2.5, 196b17– 21, which I presented for the first time in my book I fondamenti della causalità naturale (2006).
Giovanna R. Giardina
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
End-to-End Nanophotonic Inverse Design for Imaging and Polarimetry [PDF]
, 2020 By co-designing a meta-optical front end in conjunction with an image-processing back end, we demonstrate noise sensitivity and compactness substantially superior to either an optics-only or a computation-only approach, illustrated by two examples ...
Raphaël Pestourie (14359305) +5 more
core +1 more source
A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR)
Beilstein Journal of Organic Chemistry, 2020 Systems glycobiology aims to provide models and analysis tools that account for the biosynthesis, regulation, and interactions with glycoconjugates.
Benjamin P. Kellman +19 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
PrEP Grade A recommendation for HIV prevention [PDF]
, 2021 Title from PDF caption (viewed on December 30, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Jay W. Winton the much-travelled ventriloquist, introducing McGinty, from Australia. [PDF]
, 1909 Caption title.; "Aug. 16 1909".; Shows held in the Foresters Vaudeville Theatre, Mile End, England.; Also available online http://nla.gov.au/nla.aus-vn4773476.Introducing McGinty, from ...
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