Results 81 to 90 of about 7,340,393 (314)

End-Capping Strategies for Triggering End-to-End Depolymerization of Polyglyoxylates

open access: yes, 2016
Polymers that undergo end-to-end depolymerization in response to the cleavage of a stimuli-responsive end-cap are promising for diverse applications from drug delivery to responsive coatings and plastics.
Elizabeth R. Gillies   +5 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The Adjustment That Didn’t Happen: The Duty to Promote the Happiness of Others in Kant’s System of Ethics

open access: yesRUDN Journal of Philosophy
Labouring upon the groundwork of “critical” ethics, Kant opposed its principle, the categorical imperative, to the principles of naturalistic morals, and, among others, to the principle of personal happiness.
Andrey K. Sudakov
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PrEP Grade A recommendation for HIV prevention. Spanish

open access: yes, 2021
Title from PDF caption (viewed on December 30, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

What you need to know about monkeypox (HMPXV)

open access: yes, 2022
Title from PDF caption (viewed on October 4, 2022).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of

core  

Explaining the Status and Function of Imaginative Faculty in Rational Emission of Behavior and Action with an Emphasis on Mulla Sadra’s Doctrine of Soul [PDF]

open access: yesاخلاق وحیانی, 2016
Ibn Sina explains the emission of the human conscious-rational action by practical reason utilization of imaginative faculty and the companionship of these two.
Mohammad-Hoseyn Vafa’iyan   +1 more
doaj  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Investigating Adaptation and Transfer Learning for End-to-End Spoken Language Understanding from Speech

open access: yes, 2019
International audienceThis work investigates speaker adaptation and transfer learning for spoken language understanding (SLU). We focus on the direct extraction of semantic tags from the audio signal using an end-to-end neural network approach.
Caubrière, Antoine   +5 more
core   +1 more source

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