Results 61 to 70 of about 7,340,393 (314)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Happiness as an end: a critique of Aristotle’s rational eudaemonism
Inkanyiso, 2018 This paper examines Aristotle’s concept of happiness as encapsulated in his Nicomachean Ethics. Aristotle argues that happiness is the supreme practical good because it is perfect, final, self-sufficing and complete in itself.
Edward U. Ezedike
doaj +1 more source
AMPK-Nrf2 Signaling Pathway in Phrenic Motoneurons following Cervical Spinal Cord Injury
Antioxidants, 2022 High spinal cord injuries (SCI) induce the deafferentation of phrenic motoneurons, leading to permanent diaphragm paralysis. This involves secondary injury associated with pathologic and inflammatory processes at the site of injury, and at the level of ...
Pauline Michel-Flutot +5 more
doaj +1 more source
End-to-End Training of a Large Vocabulary End-to-End Speech Recognition System [PDF]
2019 IEEE Automatic Speech Recognition and Understanding Workshop (ASRU), 2019 In this paper, we present an end-to-end training framework for building state-of-the-art end-to-end speech recognition systems. Our training system utilizes a cluster of Central Processing Units(CPUs) and Graphics Processing Units (GPUs). The entire data reading, large scale data augmentation, neural network parameter updates are all performed "on-the ...
Chanwoo Kim 0001 +12 more
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Modeling transcriptomic age using knowledge-primed artificial neural networks
npj Aging and Mechanisms of Disease, 2021 The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. However, beyond their
Nicholas Holzscheck +12 more
doaj +1 more source
AmeriQuests, 2015 Video Synopsis: End, End, End is a meditation on the fragmentary nature of thoughts, memories, and emotions. Combining found recordings of a man marking the beginning and end of analog audio tapes with a collage of images of the natural world, this experimental short weaves in and out of the past and present, stopping along the way to ...
openaire +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
A Reply to John Dudley on Aristotle, Physics 2.5, 196b17–21
Peitho, 2017 In this article, I restate the interpretation of Aristotle’s Ph. 2.5, 196b17– 21, which I presented for the first time in my book I fondamenti della causalità naturale (2006).
Giovanna R. Giardina
doaj +1 more source