Results 151 to 160 of about 3,009,219 (314)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Management of Common Medical Conditions in End-Stage Kidney Disease by the General Practitioner
Turkish Journal of Nephrology, 2023 Emran El-Alali, Emad Al-Jaber
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Simulation of the performance of WALES based on an end-to-end model
, 2004 WALES (Water Vapour Lidar Experiment in Space) is one of the experiments considered by ESA for selection as Earth Explorer Core mission in the frame of the Earth Observation Envelope Programme.
Kiemle, Christoph +15 more
core
End conditions for interpolatory cubic splines with unequally spaced knots
, 1980 A class of end conditions is derived for cubic spline interpolation at unequally spaced knots. These conditions are in terms of function values at the knots and lead to 0 (h4) convergence uniformly on the interval of ...
Papamichael, N., Behforooz, G.H.
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
BMC Oral HealthBackground Although associations between periodontitis and metabolic diseases are established, published data about the correlation of advanced glycation end products (AGEs) and periodontal inflammation are scarce.
M. Cyris +8 more
doaj +1 more source
Front-end Conditions for Product-service System Design
, 2016 This research shows the preliminary results of ongoing research in the understanding of front-end conditions that lever the organization's general disposition toward creating new product-service systems.
Dewit, Ivo
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Optimizing the conditions for the DNA two end immobilization
, 2022 We are studying the conditions required to optimize the two end DNA immobilization on the PEG functionalized ...
Gautam, Dinesh
core