Results 141 to 150 of about 3,009,219 (314)
Physiologic conditions at the beginning and end of ventilation.
, 2017 Physiologic conditions at the beginning and end of ventilation.
Li-Fu Li (84336) +6 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Continental welfare states in Europe confronted with the end-of-career inactivity trap: A major challenge to social protection in an aging society. CES Working Paper, no. 81, 2002 [PDF]
, 2002 The paper is an attempt to assess continental welfare state reforms that use the window of the end-of-career inactivity trap. The question addressed is: what is the most effective way to break up the vicious circle of early exit from the labor market ...
Guillemard, Anne-Marie.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Influence of end-conditions during tube hydroforming of aluminum extrusions
, 2004 Tube hydroforming experiments were conducted to develop the forming limit diagram of AA6082-T4 by utilizing three types of end-conditions: (i) free-end , (ii) pinched-end or fixed-end and (iii) forced-end . It was found that free-end hydroforming
Loukus, Adam +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
End conditions of piano strings
, 2007 International audienceThe research of a trade-off between loudness and sustain (duration) is a major issue for piano designers and manufacturers. The way the energy of vibration is transferred from the piano string to the soundboard depends on the end ...
Ege, Kerem, Chaigne, Antoine
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The end of lifelong learning: A post-human condition?
Studies in the Education of Adults, 2010 This article explores the significance of theories of the post-human for lifelong learning. Drawing upon the works of Karen Barad and Bruno Latour, it suggests that education has focused on the learning subject as a result of an a priori assumption of a separation of matter from meaning, the object from the subject.
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source