Results 51 to 60 of about 372,052 (223)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

A Low-Cost RGB-D Sensing Front-End for Stable 3D Hand Landmark Reconstruction Using MediaPipe and ZED2 Stereo Depth

Sensors
Stable three-dimensional hand landmark reconstruction using low-cost RGB-D sensors is important for human–computer interaction, robot teleoperation, and vision-based motion analysis. RGB-based hand landmark detectors provide stable semantic 2D landmarks,
Laixin Peng, Tiansheng Liu, Bingwei He
doaj   +1 more source

Reliable Path Selection and Opportunistic Routing Protocol for Underwater Wireless Sensor Networks

IEEE Access, 2020
The increased need to gather scientific data and the renewed drive to explore underwater natural resources has led more and more researchers to study the underwater environment.
Muhammad Ismail, Mazhar Islam, Ibrar Ahmad, Farrukh Aslam Khan, Abdul Baseer Qazi, Zawar Hussain Khan, Zahid Wadud, Mabrook Al-Rakhami   +7 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Region Aware Proactive Routing Approaches Exploiting Energy Efficient Paths for Void Hole Avoidance in Underwater WSNs

IEEE Access, 2019
Nowadays, constrained battery life expectancy is an important issue for reliable data delivery in an Underwater Wireless Sensor Network (UWSN). Conventional transmission methodologies increase the transmission overhead, i.e., the collision of packets ...
Zahoor Ali Khan, Muhammad Awais, Turki Ali Alghamdi, Adia Khalid, Aisha Fatima, Mariam Akbar, Nadeem Javaid   +6 more
doaj   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Multi-Field Coupling Numerical Analysis and Experimental Validation of Surface-Textured Metal Seals in Roller Cone Bits

Lubricants
Metal seals play a crucial role in ensuring the dependable functioning of the bearing system in roller cone bits. Due to the intricate nature of downhole conditions, the microstructure design of sealing end faces, specifically the surface texture, is ...
Yi Ma, Ziang Li, Ziyang Yuan, Xiangkai Meng, Xudong Peng, Jinbo Jiang   +5 more
doaj   +1 more source

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

Experimental Study on Well Construction Process and Bearing Capacity Characteristics of Deepwater Suction Pile

Shiyou jixie, 2022
At present, well construction by shallow suction pile is mostly used in offshore drilling, but the relevant calculatioNmethod is complex and is not suitable for deepwater well construction conditions.
Liu Shujie, Huang Yi, Liu Hexing, Zhang Minghe, Li Lei, Zheng Jinlong   +5 more
doaj