Results 61 to 70 of about 1,611,302 (259)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Abyssal Atlantic circulation during the Last Glacial Maximum: Constraining the ratio between transport and vertical mixing [PDF]

, 2010
The ocean’s role in regulating atmospheric carbon dioxide on glacial‐interglacial timescales remains an unresolved issue in paleoclimatology. Reduced mixing between deep water masses may have aided oceanic storage of atmospheric CO_2 during the Last ...
Andrews, Boyle, Broecker, Curry, Curry, D. C. Lund, Duplessy, Duplessy, Ganachaud, Gebbie, Gherardi, Gouretski, Herguera, Hodell, J. F. Adkins, Kallel, Keeling, Keigwin, Kim, Knox, Kunze, Large, Ledwell, LeGrand, LeGrande, Lumpkin, Lynch-Stieglitz, Marchal, Monnin, Morris, Munk, Neftel, Ninnemann, Nurser, Oppo, Ostermann, Plumb, Polzin, R. Ferrari, Robinson, Sarmiento, Schlosser, Siegenthaler, Sigman, Speer, Speer, Stammer, Toggweiler, Wunsch, Wunsch, Zahn   +50 more
core   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Numerical modeling of laminar free overfall in triangular channels

Ain Shams Engineering Journal
Design of open channel transport and flow measurement systems for highly viscous liquids requires accurate modelling of laminar free overfall. In this study, a computational fluid dynamics model was developed to investigate subcritical laminar free ...
Primož Drešar, Marko Hočevar, Marko Blagojevič, Benjamin Bizjan   +3 more
doaj   +1 more source

Massive Lyman Break Galaxies at z~3 in the Spitzer Extragalactic First Look Survey [PDF]

, 2007
We investigate the properties of 1088 Lyman Break Galaxies (LBGs) at z~3 selected from a ~2.63$ deg2 sub-region of the First Look Survey field using the ground-based multi-color data and the Spitzer Space Telescope mid-infrared data at 3--8 and 24 um ...
Bower R. G., Condon J. J., Hyunjin Shim, Lin Yan, Lisa Storrie‐Lombardi, Myungshin Im, Phillip Choi, Simcoe R. A., Williams L. L. R.   +8 more
core   +2 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Localization of transversal cracks in sandwich beams and evaluation of their severity [PDF]

, 2014
An algorithm to assess transversal cracks in composite structures based on natural frequency changes due to damage is proposed. The damage assessment is performed in two steps; first the crack location is found, and afterwards an evaluation of its ...
Abdel Wahab, Magd, Gillich, GR, Praisach, ZI, Vasile, O   +3 more
core   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source