Results 181 to 190 of about 2,253,032 (266)

Accuracy and Equity of the End-of-Life Care Index in Predicting 1-Year Mortality.

JAMA Netw Open
Kohn R, Courtright KR, Grau-Sepulveda M, Olsen MK, Madden VL, Sewell B, Sheu D, Ahmad YS, Auriemma CL, Nimetz A, Dennos A, Hart KW, Creekmur B, Lee J, Nau CL, Nguyen HQ, Wang S, Boyer G, Lundstrom T, Postema L, Roth DJ, Vandewarker J, Halpern SD, Lokhnygina Y.   +23 more
europepmc   +1 more source

End-of-life decision-making in very old critically ill patients. [PDF]

Eur Geriatr Med
Sviri S, Nagata I, Szczeklik W, Sprung CL.   +3 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Futile Radiotherapy for Patients With Cancer Near the End of Life.

JAMA Netw Open
Deshane A, Freret M, Brennan VS, Iyengar P, Gomez DR, Yerramilli D, Xu AJ.   +6 more
europepmc   +1 more source

Antimicrobial use at the end of life: a retrospective cohort study. [PDF]

Sci Rep
Sandqvist K, Ekström M.
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Noticing and responding to end-of-life suffering in the PICU: A co-designed conceptual framework for nursing practice. [PDF]

Intensive Crit Care Nurs
Broden Arciprete EG, Michelson KN, Feder SL, Marr JW, Al-Roub N, Gouda SR, Jones AM, Schopen AB, Tapper AK, Pasek TA, Kelly RJ, Morris LR, Olszewski AE, Gallagher C, Taylor JA, McCarthy SB, Snaman JM, Ananth P.   +17 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Considerations of equity in the development of tools that identify and respond to end-of-life carer support needs: a scoping review. [PDF]

BMJ Open
Long HA, Rowland C, Higgerson J, Hall A, Urwin S, Brooks J.   +5 more
europepmc   +1 more source