Results 131 to 140 of about 167,116,004 (280)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Reforms recommended for end of life choices
, 2016 The Victorian Parliament\u27s Legal and Social Issues Committee to inquire into, consider and report, no later than 31 May 2016, on the need for laws in Victoria to allow citizens to make informed decisions regarding their own end of life choices and, in
Parliament of Victoria- Legal and Social Issues Committee
core
The Role of Social Workers in the End-of-Life Debate
Columbia Social Work Review, 2019 Although many articles and books discuss the ethics of end-of-life issues, few publications are written specifi cally for social workers and social work students.
Jennifer Zaleski
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
End-of-life disposal in inclined geosynchronous orbits
, 2020 The first version (2002) of the Mitigation Guidelines issued by the Inter-Agency Space Debris Coordination Committee (IADC) defined a toroidal Geosynchronous Protected Region, extending 200 km below and above the geosynchronous altitude of 35,786 km, and
Anselmo L, Pardini C
core
Improving End-of-Life Communication and Decision-making in Ontario [PDF]
, 2013 Two-page overview of what was learned from a citizen panel on the topic of improving end-of-life communication and decision-making in ...
McMaster Health Forum
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Creating space to discuss end-of-life issues in cancer care. [PDF]
Patient Educ Couns, 2019 Cortez D, Maynard DW, Campbell TC.
europepmc +1 more source