Results 141 to 150 of about 167,116,004 (280)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

End of Life Law in Australia

, 2016
End of Life Law in Australia provides accurate, practical and relevant information to assist you in navigating the challenging legal issues that can arise with end of life decision-making.\ud \ud This website is an initiative of the Australian Centre for
White, Benjamin P., Willmott, Lindy, Neller, Penny   +2 more
core  

An overview of end-of-life issues in a cardiology department. Is the mode of death worse in the cardiac intensive care unit? [PDF]

J Geriatr Cardiol, 2019
Vicent L, Bruña V, Devesa C, García-Carreño J, Sousa-Casasnovas I, Juárez M, Fernández-Avilés F, Martínez-Sellés M.   +7 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Older persons' perceptions about advanced directives and end of life issues in a geriatric care setting in Southwestern Nigeria. [PDF]

Pan Afr Med J, 2019
Cadmus EO, Adebusoye LA, Olowookere OO, Olusegun AT, Oyinlola O, Adeleke RO, Omobowale OC, Alonge TO.   +7 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

End-of-life care and dying : issues raised by staff supporting older people with intellectual disability in community living services

, 2012
End-of-life care and dying : issues raised by staff supporting older people with intellectual disability in community living ...
Angela Dew (13065897), M Wiese (9867746), G Howarth (9863987), R Stancliffe (13646980), Susan Balandin (13060020)   +4 more
core  

End-of-life issues in older adults: Emotional and social factors that shape end-of-life experiences. [PDF]

Adv Psychiatry Behav Health
McDarby M, Kozlov E, McConnell KM.
europepmc   +1 more source

Racial Disparities in End-of-Life Issues in Patients with Chronic Kidney Disease. [PDF]

Am J Nephrol, 2016
Norris KC, Nicholas SB.
europepmc   +1 more source