Results 81 to 90 of about 7,085,195 (294)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Inumana intertestualità: appunti sulla citazione nelle Poesie della fine del mondo
Cuadernos de Filología Italiana, 2006 Delfini’s way of writing is often tinged with intertextual quotations or allusions which prove to be functional within his work. In particular, the Poesie della fine del mondo, where the phenomenon acquires a status of unprecedented importance, are ...
Gian Luca Picconi
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Intersecting end of the world branes
Journal of High Energy PhysicsDynamical cobordisms implement the swampland cobordism conjecture in the framework of effective field theory, realizing codimension-1 end of the world (ETW) branes as singularities at finite spacetime distance at which scalars diverge to infinite field ...
Roberta Angius +2 more
doaj +1 more source
A wise person plants a tree a day before the end of the world: coping with the emotional experience of climate change in Poland. [PDF]
Curr Psychol, 2022 Zaremba D +9 more
europepmc +1 more source
An exploratory study to design an adaptive hypermedia system for online-advertisement [PDF]
, 2013 The revolutionary world of the World Wide Web has created an open space for a multitude of fields to develop and propagate. One of these major fields is advertisement.
Al Qudah, Dana +2 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Towards Data-driven Simulation of End-to-end Network Performance Indicators
, 2019 Novel vehicular communication methods are mostly analyzed simulatively or analytically as real world performance tests are highly time-consuming and cost-intense.
Sliwa, Benjamin, Wietfeld, Christian
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source