Results 71 to 80 of about 11,034,532 (299)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti +11 morewiley +1 more sourceNew susceptibility Loci associated with kidney disease in type 1 diabetes [PDF]
, 2012 Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation.Benjamin J. Keller (135013), Swan, E.J., Zerbini, G., Huang H., Savage, D.A., Groop L., He, Bing, Martin, Finian, Maxwell, Alexander P., Lefebvre P., Claes Ladenvall (135128), Isakova Tamara, Rosengård-Bärlund, Milla, Maestroni S., Cimponeriu Danut, Bing He, Ahola, A., Claes Ladenvall, Gill, G.V., Raija Lithovius (135051), Syreeni A., Ahola, Aila J., Aila J Ahola, Tregouet, David-Alexandre, Palmer, C., McKnight Amy Jayne, Emma Ahlqvist (135003), Kretzler M., Joel N Hirschhorn, Markku Lehto (135047), Kustaa Hietala (135040), Möllsten Anna, Anne-May Osterholm, Soro-Paavonen, A., McKnight, Amy Jayne, Robert L. Hanson (135175), Hosseini S. Mohsen, Hirschhorn, Joel, Österholm Anne-May, Tregouet David-Alexandre, Groop Leif, Groop, L., Kretzler, M., Taylor Andrew, Stavarachi Monica, Martin Finian, Eugen Mota, Böger C.A., Kustaa Hietala, Heikkilä O., Hanson, R.L., Maxwell, Alexander P; id_orcid, Tolonen Nina, Zerbini G., Bain, Stephen C., Kytö, Janne, He, Bin, Ahlqvist Emma, Hosseini, S.M., Wadén, Johan, Wadén J., Robert L Hanson, Cinzia Sarti, Groop Per-Henrik, Mollsten, Anna, Williams W.W., Cristian Serafinceanu, Andrew D Paterson, Mirel, Daniel B, Gu, Tianwei, Rigalleau V., Isakova T., Harjutsalo V., Pierre Lefebvre, Gordin D., Nina Tolonen, Syreeni, Anna, Bull S.B., Alhenc-Gelas, F., Lahermo Päivi, Boright, Andrew P, Raija Lithovius, Salem, Rany M., Keller, B., Candace Guiducci (135108), Mihai Ioana (135158), Soro-Paavonen Aino, Deshmukh H.A., Hans-Henrik Parving (135117), Sadlier, D., Österholm A.-M., Ahola Aila J., Saraheimo, Markku, Sarah Prior, Denise M Sadlier, Bing He (135034), Tregouet D.-A., Tolonen, Nina Emilia, Groop P.-H., Tikkanen, H., Palmer, Cameron, et al., Boright, A.P., Florez, Jose, Gianpaolo Zerbini, Aino Soro-Paavonen, Mota, E., Lahermo, Päivi, Hietala, Kustaa, Ladenvall, Claes, Swan E.J., Groop, Per-Henrik, Stavarachi M., Brismar, Kerstin, Williams, W., Thorn, L.M., Maria Mota (135162), Hirschhorn Joel N., Maestroni Silvia, Alhenc-Gelas, Francois, David A Savage, Harshal A. Deshmukh (135008), Söderlund Jenny, Osterholm, Anne-May, Paterson, Andrew D., Alexander P Maxwell, Waggott, D., Mäkinen, Ville-Petteri, Guiducci Candace, Salem R.M., Milla Rosengård-Bärlund (135064), McKay, Gareth J., Rosengård-Bärlund Milla, Savage D.A., Jaakko Tuomilehto, Rossing, P., Aino Soro-Paavonen (135070), Lithovius Raija, Maestroni, Silvia, David-Alexandre Tregouet (4350982), Silvia Maestroni, Rigalleau Vincent, Monica Stavarachi, DCCT/EDIC Research Group, Fagerholm E., Lehto M., Alexander P. Maxwell (135219), Rossing Peter, Prior S., Alhenc-Gelas F., McKnight, A.J., Danut Cimponeriu (135155), Henrik Falhammar, Hietala K., Fagerholm Emma, Markku Saraheimo, Deshmukh, H.A., François Alhenc-Gelas (135130), Möllsten A., Deshmukh Harshal A., Jenny Söderlund, Kytö Janne, Boright, Andrew P., Tarnow, Lise, Maestroni, S., Ahola, Aila, Tryggvason Karl, Rigalleau, Vincent, Jose C. Florez (114792), Ronan Roussel (101806), Elizabeth J. Swan (134990), Gordin Daniel, Prior Sarah, Williams, Winfred W., Salem, Rany M, Kretzler Matthias, Nelson R.G., Pitkäniemi J., Lund University., Mirel Daniel B., Söderlun, Jenny, Hans-Henrik Parving, Catherine Godson, Ronan Roussel, Ahlqvist E., Forsblom, C., David-Alexandre Tregouet, Heikkilä, Outi, Panduru Nicolae Mircea, Karl Tryggvason, Bull, S.B., Rossing, Peter, Cinzia Sarti (135068), Gill G.V., Keller, Benjamin J., McKnight, A., Brennan, E., Keller, B.J., Johan Wadén (135095), Bain Stephen C., Hadjadj S., Keller, Benjamin J, Hietala Kustaa, Lehto Markku, Matthias Kretzler (135179), McKnight, Amy Jayne; id_orcid, Gill, Geoffrey V, Tryggvason K., Gill Geoffrey V., Tamara Isakova, Lahermo P., Ahola, Aila J, Päivi Lahermo (95619), Guiducci C., Prior, S., Nicolae Mircea Panduru, Boright Andrew P., Serafinceanu Cristian, Andrew P Boright, Daniel B Mirel, Gu Tianwei, Godson, C., Maxwell A.P., Taylor, Andrew, Maxwell, A.P., Emma Fagerholm, Ville-Petteri Mäkinen, Roussel R., Harjutsalo, Valma, Heikki Tikkanen, Tryggvason, K., Mirel, Daniel B., Tolonen N., Carol Forsblom (134970), Sarti, C., Hosseini, S. Mohsen, Henrik Falhammar (135149), Huang, H., Saraheimo Markku, Parkkonen, Maija, Catherine Godson (93633), Soro-Paavonen, Aino, Tarnow, L., Mäkinen Ville-Petteri, Tikkanen Heikki, Lajer M., Amy Jayne McKnight (134964), Sadlier, Denise M., Lefebvre, P., Andrew Taylor, McKay Gareth J., Hosseini S.M., Sarti, Cinzia, Heikki Tikkanen (135079), Tuomilehto J., Bain, S.C., Martin, F., Mota, Maria, Fagerholm, Emma, Tianwei Gu (135152), Sadlier, Denise M, Per-Henrik Groop, Peter Rossing, Tarnow L., Maija Parkkonen, Sadlier Denise M., Per-Henrik Groop (135217), Milla Rosengård-Bärlund, Ville-Petteri Mäkinen (74272), Eugen Mota (135165), Florez J.C., Rany M. Salem (134961), Gareth J McKay, Daryl Waggott (135190), Parving H.-H., Joel N. Hirschhorn (131545), Leif Groop (12005), Ahlqvist, Emma, Syreeni Anna, Ahlqvist, Emma,, Gu, Harvest F., S. Mohsen Hosseini (135113), Anna Maestroni (135141), Pierre Lefebvre (135133), Serafinceanu C., Zerbini, Gianpaolo, Emma Fagerholm (135023), Winfred W. Williams (134981), Vincent Rigalleau, Peter Rossing (135121), Anna Möllsten (135153), Robert G. Nelson (135177), Niina Sandholm (134957), Ladenvall Claes, Palmer C., Fagerholm, E., Forsblom C., Guiducci, Candace, Deshmukh, H., Eoin P. Brennan (134968), Heikkila, O., Ahola A.J., He B., Rosengård-Bärlund M., Williams, Winfred, Gill, Geoffrey V., Lise Tarnow (135125), Anna Syreeni, Florez Jose C., Gianpaolo Zerbini (135187), Eoin P Brennan, Harshal A Deshmukh, Andrew D. Paterson (135194), Jaakko Tuomilehto (65635), McKay, Gareth J; id_orcid, Cimponeriu, Danut, Stavarachi, Monica, Mäkinen, V., Cameron Palmer, Kerstin Brismar (135185), Sandholm, Niina, Valma Harjutsalo (135029), Cameron Palmer (134993), Lefebvre, Pierre, Kyto, J., Thorn Lena M., Parving, Hans-Henrik, Prior, Sarah, Ladenvall C., Lena M. Thorn (135076), Deshmukh, Harshal A, Nelson, Robert G., Anna Syreeni (135072), Hadjadj Samy, Salem, R., Heikkilä Outi, Godson, Catherine, Maria Lajer (135188), Harvest F Gu, Pitkäniemi, Janne, Lithovius, Raija, Maija Parkkonen (135059), Isakova, T., Lehto, Markku, Waggott, Daryl, Bull Shelley B., Harjutsalo Valma, Lena M Thorn, Mirel, D.B., Aila J. Ahola (135020), Roussel Ronan, Mollsten, Anna,, Tolonen, Nina, Päivi Lahermo, Deshmukh, Harshal A., Ahlqvist, E., Hadjadj, S., Rigalleau, V., Outi Heikkilä, Danut Cimponeriu, Sadlier D.M., Swan, E., Gu H.F., Wadén Johan, Swan, Elizabeth J, Groop, Leif,, Panduru, Nicolae Mircea, Mäkinen, V.P., Hanson, Robert L., Paterson A.D., Daryl Waggott, Maria Mota, Daniel Gordin, Söderlund J., Bain S.C., Forsblom, Carol, Falhammar Henrik, Maxwell Alexander P., Rossing P., Helen M Colhoun, Marre Michel, Mota M., Pitkäniemi, Janne Mikael, Prior, Sarah Virginie, Janne Pitkäniemi, Carol Forsblom, Hirschhorn J.N., Gordin, D., Samy Hadjadj (91107), Gu T., Zerbini Gianpaolo, Sandholm, N., Sandholm N., Groop, P.H., McKnight A.J., Guiducci, C., Lithovius R., Swan, Elizabeth J., Saraheimo M., S Mohsen Hosseini, EDIC Research Group, DCCT/, Cristian Serafinceanu (135168), Florez, J.C., Michel Marre (91106), Savage, David A., Sarti C., Parving, H.H., Nelson Robert G., Tikkanen H., Elizabeth J Swan, Serafinceanu, C., Thorn, Lena M, Ioana M., Tarnow Lise, Mota, Eugen, Tikkanen, Heikki Olavi, Salem Rany M., Williams, Winfred W, Soderlund, J., Brismar K., Marre M., Karl Tryggvason (135087), Helen M. Colhoun (130220), François Alhenc-Gelas, Hanson R.L., Savage David A., Stephen C. Bain (135204), Candace Guiducci, Boright A.P., Andrew P. Boright (135000), Godson C., Groop, Per Henrik, Brismar, K., Niina Sandholm, Kytö J., Marre, Michel, Tregouet, D.A., Parkkonen M., Marre, M., Denise M. Sadlier (134987), Pitkäniemi Janne, Amy Jayne McKnight, Kerstin Brismar, Shelley B. Bull (135189), Falhammar, Henrik, Soro-Paavonen A., Brennan Eoin P., Waden, J., Palmer Cameron, Savage, David A, Maestroni, Anna, Janne Kytö, Maestroni, A., Geoffrey V Gill, Vincent Rigalleau (135135), Martin F., Brennan, Eoin P., Brismar Kerstin, Taylor, A., Colhoun H.M., Panduru N.M., Geoffrey V. Gill (135099), Ioana, Mihai, Mota Maria, Silvia Maestroni (135145), Williams Winfred W., Hirschhorn, J.N., Lefebvre Pierre, Michel Marre, Nelson, R.G., Palmer, Cameron Douglas, Palmer, Cameron D., Janne Pitkäniemi (28917), McKay G.J., Keller B.J., Taylor A., Ioana, M., Winfred W Williams, Falhammar H., Shelley B Bull, Outi Heikkilä (135037), Ladenvall, C., Gordin, Daniel, Mihai Ioana, Paterson Andrew D., Isakova, Tamara, Andrew Taylor (135110), Sarah Prior (135104), Bull, Shelley B., Colhoun Helen M., Monica Stavarachi (135172), Sarti Cinzia, Johan Wadén, Stephen C Bain, Mollsten, A., McKay, G., Mota Eugen, Lajer Maria, Lajer, Maria, Hanson Robert L., Thorn, Lena M., Benjamin J Keller, Anne-May Österholm (135054), Gu, T., Colhoun, Helen M., Cimponeriu D., David A. Savage (135199), Lajer, M., Falhammar, H., He Bing, Emma Ahlqvist, Lise Tarnow, Janne Kytö (135043), Dahlström, Emma Helena, Colhoun, H.M., Finian Martin (135209), Ioana Mihai, Serafinceanu, Cristian, Mirel D.B., Huateng Huang, Anna Möllsten, Swan Elizabeth J., Maestroni Anna, Syreeni, A., Huang, Huateng, Roussel, R., Hirschhorn, Joel N., Panduru, N.M., Samy Hadjadj, Mota E., Roussel, Ronan, Thorn L.M., Matthias Kretzler, Thorn, Lena, Finian Martin, Godson Catherine, Nina Tolonen (135081), Keller Benjamin J., Jenny Söderlund (135069), Nicolae Mircea Panduru (135181), Harvest F. Gu (135183), Alhenc-Gelas François, Sandholm Niina, Gu, H.F., Rany M Salem, Valma Harjutsalo, Florez, Jose C., Tikkanen, Heikki, Jose C Florez, He, B., Maria Lajer, Brennan E.P., Robert G Nelson, Stavarachi, M., Huang Huateng, Gordin, Ted Daniel, Daniel B. Mirel (110265), Gu Harvest F., Österholm, Anne May, Tryggvason, Karl, Tianwei Gu, Mota, M., Markku Lehto, Brennan, Eoin P, Söderlund, Jenny, Kretzler, Matthias, Mäkinen V.-P., Huateng Huang (135018), Parkkonen Maija, Boright, A., Tamara Isakova (134971), Waggott D., Leif Groop, Maestroni A., Forsblom Carol, Hadjadj, Samy, Groop, Leif, Paterson, A.D., Anna Maestroni, Daniel Gordin (135027), Gareth J. McKay (134975), Parving Hans-Henrik, Ladenvall, Claes,, Tuomilehto Jaakko, Cimponeriu, D., Waggott Daryl, Tuomilehto, Jaakko, Markku Saraheimo (135067), Sadlier, DM, McKnight, AJ, Williams, WW, Brennan, EP, Forsblom, C, Sandholm, N, Makinen, V-P, Salem, RM, McKay, GJ, Isakova, T +597 morecore +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceThe eGFR-C study: accuracy of glomerular filtration rate (GFR) estimation using creatinine and cystatin C and albuminuria for monitoring disease progression in patients with stage 3 chronic kidney disease - prospective longitudinal study in a multiethnic population [PDF]
, 2014 Background: Uncertainty exists regarding the optimal method to estimate glomerular filtration rate (GFR) for disease detection and monitoring. Widely used GFR estimates have not been validated in British ethnic minority populations.Sutton, AJ, Kevin Harris, eGFR-C study group (7648493), Khunti, Kamlesh, Brettell, Elizabeth A., Stevens, PE, Sutton, Andrew J., Claire C Sharpe, Lamb, EJ, Brettell, Elizabeth A, Cockwell, P, F. Loud (7648475), Sutton, Andrew J, P. E. Stevens (7648484), Sharpe, Claire C, Sharpe, CC, J. J. Deeks (7648466), Edmund J Lamb, Maarten W Taal, A. J. Sitch (7642292), Deeks, Jon J., R. S. Ottridge (7648478), Kamlesh Khunti, Elizabeth A Brettell, Taal, Maarten W., Khunti, K, Ottridge, Ryan, Lamb, Edmund J., Brettell, EA, Sutton, Andrew, Sharpe, Claire C., Ryan S Ottridge, Ottridge, Ryan S, ?, ?, N. Dalton (7648463), P. A. Kalra (7648472), Dalton, N, Kalra, PA, Neil Dalton, Taal, Maarten W, Taal, MW, Philip A Kalra, Sharpe, Claire C; id_orcid, Loud, F, K. Harris (75473), Tracy Higgins, Andrew J Sutton, Deeks, Jon J, Loud, Fiona, Dalton, Neil, Higgins, Tracy, Ottridge, RS, Higgins, T, Sitch, Alice J, Deeks, JJ, Sitch, AJ, M. W. Taal (7648490), T. Higgins (7648469), A. J. Sutton (7648487), Harris, Kevin, Kalra, Philip A, Paul Cockwell, Sitch, Alice J., Paul E Stevens, Ottridge, Ryan S., Harris, K, Deeks, Jonathan, Jon J Deeks, Stevens, Paul E., Sitch, Alice; id_orcid, E. J. Lamb (7648454), Kamlesh Khunti (171607), Fiona Loud, Stevens, Paul E, Kalra, Philip A., Alice J Sitch, Cockwell, Paul, P. Cockwell (7648460), Lamb, Edmund J, C. C. Sharpe (7648481), E. A. Brettell (7648457) +80 morecore +3 more sourcesIntrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen +10 morewiley +1 more sourceTherapeutic Challenges to End-Stage Kidney Disease in a Patient with Tetralogy of Fallot
, 2015 In this report, we describe the case of an end-stage kidney disease patient with tetralogy of Fallot (TOF). A 33-year-old female with TOF was admitted to our hospital with complaints of general fatigue and appetite loss probably due to uremic milieu. She Daisuke Nagata, Taro Sugase, Takuya Murakami, Tetsu Akimoto, Toshimi Imai, Yasuhiro Ando, Shin-ichi Takeda, Shigeaki Muto, Takuya Miki, Takahiro Masuda, Naoko Otani, Ken Ohara +11 morecore +1 more source
