Results 41 to 50 of about 932,509 (273)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Preliminary Proteomic and Metabolomic Analyses Reveal Potential Serum Biomarkers for Identifying Alveolar Echinococcosis in Mice

Veterinary Sciences
Alveolar echinococcosis (AE) is a chronic and potentially fatal zoonotic parasitic disease that seriously affects the host’s health. It is caused by the proliferation of Echinococcus multilocularis larvae within the liver.
Qing Zhang, Xiongying Zhang, Na Liu, Jia Liu, Wei Wang, Yongshun Wang, Wen Lei, Cunzhe Zhao, Wanli Ma, Shuai Guo, Huixia Cai, Jingxiao Zhang, Yufang Liu, Kemei Shi, Wen Zhang, Xiao Ma   +15 more
doaj   +1 more source

The association of adiponectin gene polymorphisms with susceptibility and progression of NAFLD in a cohort of Egyptian patients

Egyptian Liver Journal, 2021
Background Several genetic polymorphisms have been proven to play a key role in the progression of non-alcoholic fatty liver disease (NAFLD) from simple steatosis to NASH with fibrosis.
Eman M. Hasan, Rasha A. Abd Al Aziz, Dina Sabry, Hedy A. Badary, Yasmine Gaber, Ayman Yosry, Zeinab Zakaria   +6 more
doaj   +1 more source

Phylogenetic relationships of African Caecilians (Amphibia: Gymnophiona): insights from mitochondrial rRNA gene sequences [PDF]

, 2003
Africa (excluding the Seychelles) has a diverse caecilian fauna, including the endemic family Scolecomorphidae and six endemic genera of the more cosmopolitan Caeciliidae.
Duellman W.E., Gower D.J., Hillis D.M., Loveridge A., Nussbaum R.A., Nussbaum R.A., Nussbaum R.A., Nussbaum R.A., Parker H.W., Robinson M., Shimodaira H., Swofford D.L., Tamura K., Taylor E.H., Wilkinson M.   +14 more
core   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

A preliminary study of serum metabolomic profiling in male patients with acute brucellosis

Scientific Reports
Brucellosis is a significant zoonotic disease that may lead to metabolic profile changes, which remain insufficiently studied. This study utilized an ultra-high performance liquid chromatography coupled with Q Exactive-Orbitrap mass spectrometry (UHPLC ...
Shenglian Niu, Qiang Li, Jianling Wang, Jiquan Li, Yanmei Zhao, Hongmei Xue, Li Ma, Zhijun Zhao, Qingwen Zhang   +8 more
doaj   +1 more source

Spatial clusters of gonorrhoea in England with particular reference to the outcome of partner notification: 2012 and 2013 [PDF]

, 2018
Background: This study explored spatial-temporal variation in diagnoses of gonorrhoea to identify and quantify endemic areas and clusters in relation to patient characteristics and outcomes of partner notification (PN) across England, UK.
O'Brien, A, Sherrard-Smith, E, Sile, B, Simms, I, Watts, C   +4 more
core   +3 more sources

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Differences between the intestinal microbial communities of healthy dogs from plateau and those of plateau dogs infected with Echinococcus

Virology Journal
Objective Cystic echinococcosis (CE) represents a profoundly perilous zoonotic disease. The advent of viral macrogenomics has facilitated the exploration of hitherto uncharted viral territories.
Jia Liu, Xiaojie Jiang, Wen Lei, Yuan Xi, Qing Zhang, Huixia Cai, Xiao Ma, Yufang Liu, Wei Wang, Na Liu, Xiongying Zhang, Wanli Ma, Cunzhe Zhao, Bin Ni, Wen Zhang, Yongshun Wang   +15 more
doaj   +1 more source