Results 41 to 50 of about 986,907 (324)

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

A preliminary study of serum metabolomic profiling in male patients with acute brucellosis

Scientific Reports
Brucellosis is a significant zoonotic disease that may lead to metabolic profile changes, which remain insufficiently studied. This study utilized an ultra-high performance liquid chromatography coupled with Q Exactive-Orbitrap mass spectrometry (UHPLC ...
Shenglian Niu, Qiang Li, Jianling Wang, Jiquan Li, Yanmei Zhao, Hongmei Xue, Li Ma, Zhijun Zhao, Qingwen Zhang   +8 more
doaj   +1 more source

Preliminary Proteomic and Metabolomic Analyses Reveal Potential Serum Biomarkers for Identifying Alveolar Echinococcosis in Mice

Veterinary Sciences
Alveolar echinococcosis (AE) is a chronic and potentially fatal zoonotic parasitic disease that seriously affects the host’s health. It is caused by the proliferation of Echinococcus multilocularis larvae within the liver.
Qing Zhang, Xiongying Zhang, Na Liu, Jia Liu, Wei Wang, Yongshun Wang, Wen Lei, Cunzhe Zhao, Wanli Ma, Shuai Guo, Huixia Cai, Jingxiao Zhang, Yufang Liu, Kemei Shi, Wen Zhang, Xiao Ma   +15 more
doaj   +1 more source

The association of adiponectin gene polymorphisms with susceptibility and progression of NAFLD in a cohort of Egyptian patients

Egyptian Liver Journal, 2021
Background Several genetic polymorphisms have been proven to play a key role in the progression of non-alcoholic fatty liver disease (NAFLD) from simple steatosis to NASH with fibrosis.
Eman M. Hasan, Rasha A. Abd Al Aziz, Dina Sabry, Hedy A. Badary, Yasmine Gaber, Ayman Yosry, Zeinab Zakaria   +6 more
doaj   +1 more source

CactusTalk: More dragon tree tales [PDF]

, 2017
Dragon trees (Dracaena species) are updated since the last synopsis (Walker, 2001) with three new subspecies being newly described. Dracaena draco subsp. caboverdeana is endemic to the Cape Verde Islands, leaving subsp.
Walker, Colin C.
core  

Lacustrine mollusc radiations in the Lake Malawi Basin : experiments in a natural laboratory for evolution [PDF]

, 2012
In terminal Pliocene-early Pleistocene times, part of the Malawi Basin was occupied by paleo-lake Chiwondo. Molluscan biostratigraphy situates this freshwater lake either in the East African wet phase between 2.7-2.4 Ma or that of 2.0-1.8 Ma.
Gautier, Achilles, Van Damme, Dirk
core   +3 more sources

Multisectoral Convergence of Food, Nutrition and Sanitation Programs for Child Health: Evidence From Country‐Level Programs in India

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This paper underscores the critical role of multisectoral convergence in enhancing child health, particularly in addressing anemia, a micronutrient deficiency linked to both diet and sanitation. We explore how the integration of nationwide food and nutrition programs with sanitation initiatives impacts anemia in Indian children under three ...
Soumya Gupta, Payal Seth, Prabhu Pingali
wiley   +1 more source

Salmonella Typhi Stool Shedding by Patients With Enteric Fever and Asymptomatic Chronic Carriers in an Endemic Urban Setting [PDF]

, 2021
Farhana Khanam, Thomas C. Darton, James Meiring, Protup Kumer Sarker, Prasanta Kumar Biswas, Md Amirul Islam Bhuiyan, Nazmul Hasan Rajib, Susan Tonks, Andrew J. Pollard, John D. Clemens, Firdausi Qadri   +10 more
openalex   +1 more source