Results 61 to 70 of about 796,971 (236)

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

The endemic and near-endemic angiosperms of the Drakensberg Alpine Centre

South African Journal of Botany, 2006
AbstractThe Drakensberg Alpine Centre (DAC) of southern Africa supports a speciose number of angiosperms. Its compliment of 2520 native angiosperms is comparable with the native floras of northern hemisphere countries such as Germany or Switzerland, and is almost double that of Great Britain.
Carbutt, C., Edwards, T. J.
openaire   +2 more sources

Resettlement and the Special Educational Needs and Disability Code of Practice: The influence and challenges of statutory guidance from professional perspectives for young people released from prison

British Educational Research Journal, EarlyView.
Abstract This paper considers the views and experiences of local authority professionals in the policy context of the Special Educational Needs and Disability (SEND) Code of Practice (CoP) in the youth justice system in England, focusing on the resettlement transition.
Gavin Tucker, Sarah Parsons
wiley   +1 more source

In Vitro Antiplasmodial Activity and Chemical Composition of Combretum aculeatum, a Medicinal Plant From Niger

Chemistry &Biodiversity, EarlyView.
Workflow of current study. ABSTRACT Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria‐related deaths. Local medicinal plants are frequently used as traditional treatments for malaria, although their efficacy and safety are often insufficiently investigated.
Souleymane Magagi Damé, Louis Leclercq, Catherine Vonthron‐Sénécheau, Amadou Tidjani Ilagouma, Sergio Ortiz   +4 more
wiley   +1 more source

Approximating time to extinction for endemic infection models

, 2017
Approximating the time to extinction of infection is an important problem in infection modelling. A variety of different approaches have been proposed in the literature.
Clancy, Damian, Tjia, Elliott
core   +1 more source

Phytochemical Profile and Anticancer Activity of Achillea conferta Leaf Extracts: Insights Into Antioxidant Properties

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study explores the phytochemical composition and biological potential of extracts from Achillea conferta leaves, specifically hydroethanolic extract (HE), total flavonoid extract (TFE), and glycoside flavonoid extract (GFE). Phytochemical screening of HE revealed significant concentrations of phenolic compounds, flavonoids, and tannins ...
Mhmood Shakoori Yaseen, Rafah Razooq Hameed Al‐Samarrai, Mohamed Bouaziz, Sami Zouari   +3 more
wiley   +1 more source

Chemical Composition and Synergistic Antimicrobial Effects of Essential Oils From Four Commonly Used Satureja Species in Combination With Two Conventional Antibiotics

Chemistry &Biodiversity, EarlyView.
The chemical composition and the in vitro synergistic antimicrobial effects of four Satureja essential oils were investigated. Essential oils from Satureja montana and S. hortensis displayed strong antimicrobial effects, whereas S. calamintha and S. alpina exhibited relatively weaker antimicrobial activity.
Imane Abbad, Bouchra Soulaimani, Marcello Iriti, Mustapha Barakate   +3 more
wiley   +1 more source

Green Propolis Extract‐Mediated Synthesis of Biogenic Silver Nanoparticles: In Vitro Antileishmanial and Antibacterial Activities, Cytotoxicity and Ex Vivo Irritation Testing

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study describes the green synthesis, characterization, and biological evaluation of silver nanoparticles (AgNPs) obtained from green propolis (AgNPs‐PRO). Before nanoparticles synthesis, a hydroethanolic green propolis extract (GPE) was obtained through ultrasound‐assisted extraction and characterized by high‐performance liquid ...
Erica Tirzah S. Lima, Victoria L. S. Santos, Wanessa J. S. Mota, Frederico S. Martins, Ricardo L. C. de Albuquerque‐Junior, André L. S. Santos, Simone S. C. Oliveira, Jéssica A. de Lima, Adriana de Jesus Santos, Cochiran P. dos Santos, Sona Jain, Eliana B. Souto, Juliana C. Cardoso, Patrícia Severino   +13 more
wiley   +1 more source

The endemic and non-endemic vascular flora of Madagascar updated

Plant Ecology and Evolution, 2011
Background and aims - The Catalogue of the Vascular Plants of Madagascar project aims to evaluate and enumerate the native and naturalized vascular plant flora of Madagascar. In light of the past two decades of intensive collecting and taxonomic work, all relevant published literature and available specimens are being reassessed in order to evaluate ...
Callmander, Martin W., Phillipson, Peter, Schatz, George, Andriambololonera, Sylvie, Rabarimanarivo, Marina, Rakotonirina, Nivo, Raharimampionona, Jeannie, Chatelain, Cyrille, Gautier, Laurent, Lowry, Porter   +9 more
openaire   +2 more sources

Chemical Characterization of Alphitonia neocaledonica (Schltr.) Guillaumin Bark Extract and Its Anti‐Inflammatory Activities

Chemistry &Biodiversity, EarlyView.
Study of the anti‐inflammatory activities and chemical characterization of Alphitonia neocaledonica (Schltr.) Guillaumin bark extract. ABSTRACT Alphitonia neocaledonica (Schltr.) Guillaumin is a small forest tree endemic of New Caledonia traditionally used to treat rheumatic pain and dermatoses.
Karl Huet, Philippe Georgel, Mohammed Nour, Mohamed Haddad, Edouard Hnawia, Mariko Matsui   +5 more
wiley   +1 more source