Results 81 to 90 of about 796,971 (236)

Efficient and Rapid Arylation of NH₂‐Unprotected Bromobisindole Ethanamines via Suzuki‐Miyaura Coupling: Generating New Leads Against Leishmania

Chemistry – A European Journal, EarlyView.
A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Alessandro Buono, Aurora Diotallevi, Sara Maestrini, Michele Verboni, Paula Kiuru, Luca Galluzzi, Andrea Duranti, Diego Olivieri, Simone Lucarini   +8 more
wiley   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, EarlyView.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors

ChemMedChem, EarlyView.
SARS‐CoV‐2 nsp13 is a promising target to develop effective antivirals. Pursuing the studies, new indolyl derivatives to deepen SARs are designed. The newly synthesized N‐aryl indoles are active vs both nsp13‐associated activities. They exert antiviral activity vs SARS‐CoV‐2 infected cells with no cytotoxicity.
Valentina Noemi Madia, Roberta Emmolo, Elisa Patacchini, Donatella Amatore, Stefania Maloccu, Davide Ialongo, Aurora Albano, Giuseppe Ruggieri, Emanuele Cara, Laura Zarbo, Antonella Messore, Riccardo De Santis, Alessandra Amoroso, Florigio Lista, Francesca Esposito, Enzo Tramontano, Angela Corona, Roberto Di Santo, Roberta Costi   +18 more
wiley   +1 more source

Parsimony analysis of endemicity and analysis of endemicity: A fair comparison

Systematics and Biodiversity, 2015
Parsimony Analysis of Endemicity (PAE) has been compared with other methods regarding its performance to identify areas of endemism. It is frequently compared with the Analysis of Endemicity (AE), which seems to perform better than PAE to identify these areas.
openaire   +2 more sources

Cytomorphology in Tuberculous Lymphadenitis and Correlation With Acid Fast Bacilli Detection by Papanicolaou, Auramine‐Rhodamine Fluorescence and Ziehl‐Neelsen Techniques

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Tuberculosis (TB) is a common cause of lymphadenopathy in developing countries. Fine needle aspiration cytology (FNAC) along with acid fast bacilli (AFB) detection is an invaluable diagnostic test. Fluorescent methods for AFB detection have greater sensitivity as compared to the Ziehl‐Neelsen (ZN) method. Methods The incidence of TB
Seethalakshmi Viswanathan, C. P. Shroff
wiley   +1 more source

Trade‐offs among restored ecosystem functions are context‐dependent in Mediterranean‐type regions

Ecography, EarlyView.
Global biodiversity hotspots, including Mediterranean‐type ecosystems worldwide, are highly threatened by global change that alters biodiversity, ecosystem functions, and services. Some restoration activities enhance ecosystem functions by reintroducing plant species based on known relationships between plant traits and ecosystem processes.
Sebastian Fiedler, Michael P. Perring, José A. Monteiro, Cristina Branquinho, Oksana Buzhdygan, Lohengrin A. Cavieres, Elsa E. Cleland, Jordi Cortina‐Segarra, José M. Grünzweig, Jennifer A. Holm, Katja Irob, Trevor F. Keenan, Melanie Köbel, Fernando T. Maestre, Jörn Pagel, Natalia Rodríguez‐Ramírez, Paloma Ruiz‐Benito, Frank M. Schurr, Efrat Sheffer, Enrique Valencia, Britta Tietjen   +20 more
wiley   +1 more source

A zoogeographic model for the evolution of diversity and endemism in Madagascar

Ecography, EarlyView.
The delineation of zoogeographic regions is essential for understanding the evolution of biodiversity. Madagascar, characterized by high levels of endemism and habitat diversity, presents unique challenges and opportunities for such studies. Traditional global zoogeographic classifications, largely based on vertebrates, may overlook finer‐scale ...
Gabriela P. Camacho, Ana Carolina Loss, Brian L. Fisher, Bonnie B. Blaimer   +3 more
wiley   +1 more source

A test of the abundant‐center hypothesis for stream fishes

Ecography, EarlyView.
The abundant‐center hypothesis (ACH) provides a conceptual model for predicting range‐wide distributions of species abundance, suggesting that abundance peaks in the center of the geographic range and declines towards range edges. Empirical studies testing the ACH and its subsequent derivations predominantly occurred in terrestrial systems and reported
Matthew L. W. Zink, Brandon K. Peoples, Julian D. Olden, Lily M. Thompson, William K. Annis, Stephen R. Midway   +5 more
wiley   +1 more source

Moving towards better risk assessment for invertebrate conservation

Ecography, EarlyView.
Global change threatens a vast number of species with severe population declines or even extinction. The threat status of an organism is often designated based on geographic range, population size, or declines in either. However, invertebrates, which comprise the bulk of animal diversity, are conspicuously absent from global frameworks that assess ...
Robert M. Goodsell, Ayco J. M. Tack, Fredrik Ronquist, Laura J. A. van Dijk, Elzbieta Iwaszkiewicz‐Eggebrecht, Andreia Miraldo, Tomas Roslin, Jarno Vanhatalo   +7 more
wiley   +1 more source