Results 31 to 40 of about 188,726 (292)

Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network

Cancer Cell International, 2021
Background The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their regulatory mechanism in the pathogenesis of ...
Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu, Xueling Chen   +6 more
doaj   +1 more source

A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Molecular Brain, 2022
Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends on efficient protein renewal. This study aims to systematically analyze the association between anxiety / depression / neuroticism ...
Bolun Cheng, Xuena Yang, Shiqiang Cheng, Chun’e Li, Huijie Zhang, Li Liu, Peilin Meng, Yumeng Jia, Yan Wen, Feng Zhang   +9 more
doaj   +1 more source

Association between gut microbiota and longevity: a genetic correlation and mendelian randomization study

BMC Microbiology, 2022
Background Longevity is one of the most complex phenotypes, and its genetic basis remains unclear. This study aimed to explore the genetic correlation and potential causal association between gut microbiota and longevity.
Dan He, Li Liu, Zhen Zhang, Xuena Yang, Yumeng Jia, Yan Wen, Shiqiang Cheng, Peilin Meng, Chun’e Li, Huijie Zhang, Chuyu Pan, Feng Zhang   +11 more
doaj   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Geographical influences on the iodine status in pregnant women, neonates, and school-age children in China

Nutrition Journal, 2020
Background Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China.
Xiaoming Lou, Xiaofeng Wang, Guangming Mao, Wenming Zhu, Zhe Mo, Yuanyang Wang, Zhifang Wang   +6 more
doaj   +1 more source

Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort

Bone & Joint Research, 2021
Aims: Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made.
Bolun Cheng, Yan Wen, Xuena Yang, Shiqiang Cheng, Li Liu, Xiaomeng Chu, Jing Ye, Chujun Liang, Yao Yao, Yumeng Jia, Feng Zhang   +10 more
doaj   +1 more source

Hepatitis B Virus_Surface Gene Mutations and their Clinical Implications

Sudan Journal of Medical Sciences, 2017
Hepatitis B infection is a major public health problem caused by hepatitis B virus (HBV). Factors associated with host immunity such as (HBV specific T- and/or B-cell) production and antigen presentation failure and viral determinants such as the HBV ...
Yassir M. Hamadalnil, Sahar Bakheit
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Total Synthesis of Feglymycin Using Umpolung Amide Synthesis

Angewandte Chemie, EarlyView.
A total synthesis of the antiviral feglymycin is described, leveraging enantioselective umpolung amide synthesis (UmAS). The strategic use of UmAS to prepare the aryl glycine‐rich tridecapeptide reduced hazardous amide coupling agents by 50%, and replaced asymmetric synthesis reliant on toxic transition metals by organocatalysis.
Preston C. Gourville, Jade A. Bing, Rashanique D. Quarels, Sergey V. Tsukanov, Kenneth E. Schwieter, Kazuyuki Tokumaru, Amanda B. Stephens, Dawn M. Makley, Bo Shen, Abigail N. Smith, Jeffrey N. Johnston   +10 more
wiley   +2 more sources

Mitochondria-wide association study observed significant interactions of mitochondrial respiratory and the inflammatory in the development of anxiety and depression

Translational Psychiatry, 2023
The aim of this study was to investigate the possible interaction of mitochondrial dysfunction and inflammatory cytokines in the risk of anxiety and depression. We utilized the UK Biobank for the sample of this study.
Li Liu, Shiqiang Cheng, Xin Qi, Peilin Meng, Xuena Yang, Chuyu Pan, Yujing Chen, Huijie Zhang, Zhen Zhang, Jingxi Zhang, Chune Li, Yan Wen, Yumeng Jia, Bolun Cheng, Feng Zhang   +14 more
doaj   +1 more source