Results 21 to 30 of about 213,375 (263)

Challenges imposed by minor reference alleles on the identification and reporting of clinical variants from exome data

BMC Genomics, 2018
Background The conventional variant calling of pathogenic alleles in exome and genome sequencing requires the presence of the non-pathogenic alleles as genome references.
Mahmoud Koko, Mohammed O. E. Abdallah, Mutaz Amin, Muntaser Ibrahim   +3 more
doaj   +1 more source

Identification of differentially expressed and methylated genes associated with rheumatoid arthritis based on network

Autoimmunity, 2020
Rheumatoid arthritis (RA) is a multi-systemic inflammatory autoimmune disease involving peripheral joints, and the pathogenesis is not clear. Studies showed that DNA methylation and expression might also be involved in the pathogenesis of RA.
Di Zhang, ZhaoFang Li, RongQiang Zhang, XiaoLi Yang, DanDan Zhang, Qiang Li, Chen Wang, Xuena Yang, YongMin Xiong   +8 more
doaj   +1 more source

Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study

Scientific Reports, 2021
The studies on the increasing incidence of thyroid abnormalities are scarce. The aim of this current study was to ascertain the effects of geographical region on thyroid abnormalities under the context of universal salt iodization (USI).
Xiaofeng Wang, Zhe Mo, Guangming Mao, Wenming Zhu, Mingluan Xing, Xueqing Li, Yuanyang Wang, Zhifang Wang, Xiaoming Lou   +8 more
doaj   +1 more source

Endemic Chagas Disease [PDF]

, 2009
Infections by Trypanosoma cruzi are transmitted commonly by triatomines, hematophagous insects adapted to anthropophilic behavior. With its potential enzootic presence for over 90 million years, Chagas disease in humans has been documented in 9 thousand-year-old mummies from the Atacama Desert.
Antonio Teixeira, Rubens Nascimento, Nancy R Sturm   +2 more
openaire   +1 more source

Visceral leishmaniasis-hepatitis B/C coinfections: a rising necessity to triage patients for treatment

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES: Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In Sudan, VL is caused by L donovani. Most drugs used to treat VL, especially pentavalent antimony compounds (sodium stibogluconate, SSG),
Abubakr O. A. Adam, Mohamed M. M. Dafalla, Hatim A. A. Mohammed, Mohamed Y. Elamin, Brima M. Younis, Mona E. E. Elfaki, Ahmed M. Musa, Ahmed M. Elhassan, Eltahir A. G. Khalil   +8 more
doaj   +1 more source

Baseline demographic and laboratory characteristics of patients with HCC who reduce the dose of or stop sorafenib. [PDF]

Minia Journal of Medical Research
Background: One kind of primary liver cancer is hepatocellular carcinoma (HCC). When it comes to primary liver cancer, HCC is the culprit responsible for 90% of instances. Patient demographics and laboratory data related to HCC.
Enas Kamal, Nourhan Mady, Haitham Mahmoud   +2 more
doaj   +1 more source

Correction to: Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network

Cancer Cell International, 2021
An amendment to this paper has been published and can be accessed via the original article.
Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu, Xueling Chen   +6 more
doaj   +1 more source

Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network

Cancer Cell International, 2021
Background The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their regulatory mechanism in the pathogenesis of ...
Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu, Xueling Chen   +6 more
doaj   +1 more source

A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Molecular Brain, 2022
Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends on efficient protein renewal. This study aims to systematically analyze the association between anxiety / depression / neuroticism ...
Bolun Cheng, Xuena Yang, Shiqiang Cheng, Chun’e Li, Huijie Zhang, Li Liu, Peilin Meng, Yumeng Jia, Yan Wen, Feng Zhang   +9 more
doaj   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source