Results 31 to 40 of about 213,375 (263)

Endemic Diseases in the Tropics [PDF]

Nature, 1962
The Control of Disease in the Tropics A handbook for medical practitioners. By T. H. Davey and W. P. H. Lightbody. Pp. xii + 22. (London: H. K. Lewis and Co., Ltd.) 47s. 6d. net.
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Plasmodium vivax infection in Duffy-negative populations in Sudan: a systematic review and meta-analysis of host–parasite genetic adaptation

Malaria Journal
Background Sudan is one of the few African countries reporting increasing Plasmodium vivax infections despite the high prevalence of the Duffy-negative phenotype, historically considered protective against this parasite.
Mohammed Elfaki, Safaa Ahmed, Musab M. Ali Albsheer, Muzamil Mahdi Abdel Hamid   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Association between gut microbiota and longevity: a genetic correlation and mendelian randomization study

BMC Microbiology, 2022
Background Longevity is one of the most complex phenotypes, and its genetic basis remains unclear. This study aimed to explore the genetic correlation and potential causal association between gut microbiota and longevity.
Dan He, Li Liu, Zhen Zhang, Xuena Yang, Yumeng Jia, Yan Wen, Shiqiang Cheng, Peilin Meng, Chun’e Li, Huijie Zhang, Chuyu Pan, Feng Zhang   +11 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Geographical influences on the iodine status in pregnant women, neonates, and school-age children in China

Nutrition Journal, 2020
Background Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China.
Xiaoming Lou, Xiaofeng Wang, Guangming Mao, Wenming Zhu, Zhe Mo, Yuanyang Wang, Zhifang Wang   +6 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Hepatitis B Virus_Surface Gene Mutations and their Clinical Implications

Sudan Journal of Medical Sciences, 2017
Hepatitis B infection is a major public health problem caused by hepatitis B virus (HBV). Factors associated with host immunity such as (HBV specific T- and/or B-cell) production and antigen presentation failure and viral determinants such as the HBV ...
Yassir M. Hamadalnil, Sahar Bakheit
doaj   +1 more source

Spatial distribution of Anopheles gambiae sensu lato larvae in the urban environment of Yaoundé, Cameroon

Infectious Diseases of Poverty, 2019
Background The rapid and unplanned urbanization of African cities is considered to increase the risk of urban malaria transmission. The present study objective was to assess factors influencing the spatio-temporal distribution of Anopheles gambiae s.l ...
Landre Djamouko-Djonkam, Souleman Mounchili-Ndam, Nelly Kala-Chouakeu, Stella Mariette Nana-Ndjangwo, Edmond Kopya, Nadége Sonhafouo-Chiana, Abdou Talipouo, Carmene Sandra Ngadjeu, Patricia Doumbe-Belisse, Roland Bamou, Jean Claude Toto, Timoléon Tchuinkam, Charles Sinclair Wondji, Christophe Antonio-Nkondjio   +13 more
doaj   +1 more source