Results 41 to 50 of about 2,546,955 (257)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Trachomatous trichiasis and its management in endemic countries. [PDF]

, 2012
: Trichiasis is the sight-threatening consequence of conjunctival scarring in trachoma, the most common infectious cause of blindness worldwide. Trachomatous trichiasis is the result of multiple infections from childhood with Chlamydia trachomatis, which
Saul N. Rajak, Rajak, SN, Matthew J. Burton, Collin, J Richard O, Collin, J. Richard O., Burton, Matthew J., Collin, JR, Burton, Matthew J, J. Richard O. Collin, Rajak, Saul N., Burton, MJ, Rajak, Saul N   +11 more
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Hepatitis B Virus_Surface Gene Mutations and their Clinical Implications

Sudan Journal of Medical Sciences, 2017
Hepatitis B infection is a major public health problem caused by hepatitis B virus (HBV). Factors associated with host immunity such as (HBV specific T- and/or B-cell) production and antigen presentation failure and viral determinants such as the HBV ...
Yassir M. Hamadalnil, Sahar Bakheit
doaj   +1 more source

Association between gut microbiota and longevity: a genetic correlation and mendelian randomization study

BMC Microbiology, 2022
Background Longevity is one of the most complex phenotypes, and its genetic basis remains unclear. This study aimed to explore the genetic correlation and potential causal association between gut microbiota and longevity.
Dan He, Li Liu, Zhen Zhang, Xuena Yang, Yumeng Jia, Yan Wen, Shiqiang Cheng, Peilin Meng, Chun’e Li, Huijie Zhang, Chuyu Pan, Feng Zhang   +11 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research
Background Triggering receptor expressed on myeloid cells 2 (TREM2), a surface receptor predominantly expressed on myeloid cells, is a major hub gene in pathology-induced immune signaling.
Hanrui Guo, Meiling Wang, Caiya Ni, Chun Yang, Chunxue Fu, Xiaoman Zhang, Xueling Chen, Xiangwei Wu, Jun Hou, Lianghai Wang   +9 more
doaj   +1 more source

Geographical influences on the iodine status in pregnant women, neonates, and school-age children in China

Nutrition Journal, 2020
Background Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China.
Xiaoming Lou, Xiaofeng Wang, Guangming Mao, Wenming Zhu, Zhe Mo, Yuanyang Wang, Zhifang Wang   +6 more
doaj   +1 more source

Morphology of the rust fungus Puccinia boroniae revisited [PDF]

, 2005
Puccinia boroniae Henns. is a rust fungus endemic to Australia, infecting various Boronia spp. This study describes and illustrates, using light and scanning electron microscopy, the telial stage, teliospore germination and basidiospore production of ...
P.A. O’Brien, Driessen, S., O'Brien, P.A., G.E St J. Hardy, Hardy, G.E.St.J., S.A. Driessen   +5 more
core   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source