Results 81 to 90 of about 2,546,955 (257)

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Diagnostic accuracy of an automated microscope solution (miLab™) in detecting malaria parasites in symptomatic patients at point-of-care in Sudan: a case–control study

Malaria Journal
Background Microscopic detection of malaria parasites is labour-intensive, time-consuming, and expertise-demanding. Moreover, the slide interpretation is highly dependent on the staining technique and the technician’s expertise.
Muzamil M. Abdel Hamid, Abdelrahim O. Mohamed, Fayad O. Mohammed, Arwa Elaagip, Sayed A. Mustafa, Tarig Elfaki, Waleed M. A. Jebreel, Musab M. Albsheer, Sabine Dittrich, Ewurama D. A. Owusu, Seda Yerlikaya   +10 more
doaj   +1 more source

The Effect and Mechanism of KLF7 in the TLR4/NF-κB/IL-6 Inflammatory Signal Pathway of Adipocytes

Mediators of Inflammation, 2018
Objective. To investigate the role and possible molecular mechanism of Krüppel-like factor 7 (KLF7) in the TLR4/NF-κB/IL-6 inflammatory signaling pathway activated by free fatty acids (FFA). Methods. The mRNA and protein expression levels of KLF7 and the
Meixiu Zhang, Cuizhe Wang, Jinxiu Wu, Xiaodan Ha, Yuchun Deng, Xueting Zhang, Jingzhou Wang, Keru Chen, Jiale Feng, Jiaojiao Zhu, Jianxin Xie, Jun Zhang   +11 more
doaj   +1 more source

Endemic diseases and agricultural productivity: Challenges and policy response [PDF]

Contrary to Asian countries, the agricultural sector in Africa had not benefited from the green revolution success. After a long time of disinterest in the agriculture sector in Africa, several voices arise now in favour of greater efforts towards this ...
Martine Audibert
core   +2 more sources

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner, Nancy E. Martin, Danielle Smith, Eliza Kruger, Carl M.J. Kirkpatrick, Goonaseelan (Colin) Pillai, Katy Moore, Darrell Nix, Cristina Donini, Jakob P. Cramer, Edmundo Muniz, Natalia Muniz, Ernst Bos, Douglas McNair, Shyam Bhaskaran, Mark Sullivan, Dan Hartman   +16 more
wiley   +1 more source

ENDEMIC DISEASES OF THE TRANSBAIKAL REGION [PDF]

, 2020
The urgency of the problem under investigation is due to the fact that the geochemistry of the Transbaikal Region is very diverse. The aim of the article was to characterize the main diseases associated with the geochemical features of the environment ...
Mikhailova, Larisa A., Solodukhina, Maria. A., Lapa, Svetlana E., Burlaka, Natalia M.   +3 more
core   +1 more source

The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam [PDF]

, 2013
Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood.
Baker, S, Lam, HM, Thuy, Cao Thu, Boni, MF, Minh, Phamvan, Tang Chi Thuong, Phuc, HL, Phan Vu Tra My, Minh, P, Stephen Baker, Vinh, NT, Chinh, Nguyen Tran, Thompson, Corinne N, Nguyen Tran Chinh, Hoang, NV, Hoang, Nguyen Van Minh, Tuyet, PT, Campbell, James I, Vinh, H, Tuyet, Pham Thi Ngoc, Tuan, Ha Manh, Farrar, J, Boni, Maciej F, Farrar, Jeremy, Chinh, NT, Jeremy Farrar, Ha Minh Lam, Cao Thu Thuy, Nga, Tran Thi Thu, Nguyen Thi Thu Hau, Corinne N. Thompson, James I. Campbell, Ha Manh Tuan, Tuan, HM, Tra My, Phan Vu, Ha Vinh, Hau, Nguyen Thi Thu, Thuong, Tang Chi, Clements, Archie C.A., Nga, TT, Vinh, Ha, Tra My, PV, Thuy, CT, Thuong, TC, Nguyen Van Minh Hoang, PhamVan Minh, Pham Thi Ngoc Tuyet, Clements, Archie C. A., Clements, Archie CA, Thompson, CN, Maciej F. Boni, Clements, AC, Hoang Le Phuc, Campbell, JI, Phuc, Hoang Le, Campbell, James I., Thompson, Corinne N., Tran Thi Thu Nga, Lam, Ha Minh, Archie C.A. Clements, Boni, Maciej F., Nguyen Thanh Vinh, Vinh, Nguyen Thanh, Hau, NT, Baker, Stephen, Thompson, Corinne, Clements, Archie, My, Phan Vu Tra   +67 more
core   +1 more source

Velociraptor Machine Learning Quantifies Similarity to Known Cell Types and Matches Cells Across Flow and Imaging Cytometry Platforms

Cytometry Part A, EarlyView.
ABSTRACT Suspension flow cytometry enables high‐throughput cellular profiling at the single cell level, but these data lack positional information. Conversely, tissue‐based imaging cytometry techniques reveal a cell's location within the tissue architecture and can provide insight into cell biology.
Claire E. Cross, Asa A. Brockman, Rebecca A. Ihrie, Jonathan M. Irish   +3 more
wiley   +1 more source

No Association between Estrogen Receptor-Β Rs4986938 and Cancer Risk: A Systematic Review and Meta-Analysis

Iranian Journal of Public Health, 2019
Background: The association between estrogen receptor-β (ESR2) rs4986938 polymorphism and the risk of various types of cancer have been investigated in previous studies. However, the results remained disputable.
Zhaofang LI, Xiaoli YANG, Rongqiang ZHANG, Baorong LI, Di ZHANG, Qiang LI, Yongmin XIONG   +6 more
doaj   +1 more source

Photo Quiz: Globose Yeast‐Like Forms With Multiple Peripheral Buds in Urine and Cervical Cytology

Diagnostic Cytopathology, EarlyView.
ABSTRACT A 26‐year‐old immunocompetent woman with a history of noninvasive, low‐grade papillary urothelial carcinoma presented with persistent upper abdominal pain. Urine cytology, performed for bladder tumor surveillance, revealed globose, yeast‐like forms (10–30 μm) with thick walls and multiple narrowly attached peripheral buds in a “ship wheel ...
Adil Menon, Rachel Koch, Caroline Abramovich   +2 more
wiley   +1 more source