Results 81 to 90 of about 30,266,724 (254)

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Síntese e estudo de correlação estrutura-atividade de benzenossulfonilaziridinas [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciênicias Físicas e Matemáticas. Programa de Pós-Graduação em Química.Os derivados imídicos são conhecidos há várias décadas e têm sido amplamente utilizados como agentes ...
Andrade, Evilazio da Silva
core  

Endo-Orco:GFP distribution in the kinesin-2 mutant and RNAi backgrounds.

, 2021
(A-B) Surface plots for total (A) and normalised intensity (B) distributions of Endo-Orco:GFP along the ciliary OS during 0–6 hours AE in the wild-type control, homozygous Klp64Dkj353 mutant, as well as Klp64D and Klp68D RNAi backgrounds.
Akanksha Jain (153306), Anjusha Singh (11302598), Priya Dutta (535764), Swadhin Chandra Jana (9282665), Mukul Girotra (8963333), Seema Shirolikar (11302607), Lavanya Adusumilli (11302601), Diksha Kumari (11302604), Krishanu Ray (131985)   +8 more
core   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Effect of indigenous microbes on growth and blister blight disease of tea plant

Journal of Plant Protection Research, 2019
The role of the tea commodity in the economy of Indonesia is quite strategic. Various types of microorganisms in nature have been known to increase the benefit of the root function, suppress disease, and accelerate plant growth.
Fani Fauziah, Mieke Rochimi Setiawati, Eko Pranoto, Dwi Ningsih Susilowati, Yati Rachmiati   +4 more
doaj   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

akira-endo/COVID19_clustersize: Estimating the amount of superspreading using outbreak sizes of COVID-19 outside China

, 2020
Github repository archived to support a research article: Endo et al. "Estimating the amount of superspreading using outbreak sizes of COVID-19 outside China".
Endo, Akira, Funk, Sebastian, Endo, Akira (8679075), Kucharski, Adam J. (8679081), Abbott, Sam, Abbott, Sam (8679078), Kucharski, Adam J., Funk, Sebastian (6258779)   +7 more
core   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Análise da infiltração apical de um novo cimento endodôntico a base de MTA

Brazilian Dental Science, 2010
O MTA apresenta várias vantagens quando usado no selamento de perfurações e em obturações retrogradas Recentemente, um cimento endodôntico a base de MTA foi introduzido no mercado com o objetivo de obturar o canal radicular. Sendo assim, a proposta deste
Carla C.R Costa, Vicente G. N. Rocha, Sandra M Habitante, Denise P Raldi, José Luiz L. Marques   +4 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source