Results 61 to 70 of about 25,313 (227)

Cardiopulmonary function in special operations forces compared to conventional infantry soldiers

Experimental Physiology, EarlyView.
Abstract Fitness is essential to military personnel in general, especially in the special operations forces (SOF), where the demanding tasks require a high level of physical fitness and mental robustness. However, little research has been done on SOF to characterise the putative underlying cardiopulmonary adaptations that distinguish them from ...
Rasmus Syberg Rasmussen, Jakob Solgaard Jensen, Iben Elmerdahl Rasmussen, Jacob Peter Hartmann, Clara Sofie Egeberg, Anna Agnes Lytzen, Klara Nielsen, Malte Lund Adamsen, Mads Fischer, Ronan M. G. Berg   +9 more
wiley   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Epigenetics and Mechanobiology in Heart Development and Congenital Heart Disease

Diseases, 2019
Congenital heart disease (CHD) is the most common birth defect worldwide and the number one killer of live-born infants in the United States. Heart development occurs early in embryogenesis and involves complex interactions between multiple cell ...
Dillon K. Jarrell, Mallory L. Lennon, Jeffrey G. Jacot   +2 more
doaj   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical representation of methods. We implemented three biventricular geometric models (Zenger et al., 2020) with rule‐based myocardial fibre orientations (Bayer et al., 2018). We evaluated variability in the fibre orientation via four sets of parameter distributions to determine the role of the primary and imbrication angles ...
Lindsay C. R. Tanner, Anna Busatto, Jake A. Bergquist, Wilson W. Good, Brian Zenger, Gernot Plank, Akil Narayan, Karli Gillette, Rob S. MacLeod   +8 more
wiley   +1 more source

Scanning Electron Microscopic Investigations to Clarify the Role Played by the Endocardium in the Origin of Dilated Cardiomyopathy(DCM) [PDF]

, 2020
Masoud Mirzaie
openalex   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source

The influence of delayed ventricular activation on cardiac repolarization: Insights from electrocardiographic imaging

The Journal of Physiology, EarlyView.
Abstract figure legend This study examines the relationships between activation and repolarization times in epicardial reconstructed unipolar electrograms derived from ECG‐imaging in patients with normal and delayed ventricular activation. In patients with a narrow QRS‐complex, ECG‐imaging reveals significant variability in the activation ...
Karin C. Smits, Ted E.M. Lempers, Marc Strik, Job Stoks, Roel Meiburg, Matthijs J.M. Cluitmans, Paul G.A. Volders, Kevin Vernooy, Frits W. Prinzen, Uyên Châu Nguyên   +9 more
wiley   +1 more source

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium

Cell Reports, 2014
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during cardiac morphogenesis via expression and function within myocardial, neural crest, and epicardial cell populations.
Nathan J. VanDusen, Jose Casanovas, Joshua W. Vincentz, Beth A. Firulli, Marco Osterwalder, Javier Lopez-Rios, Rolf Zeller, Bin Zhou, Joaquim Grego-Bessa, José Luis De La Pompa, Weinian Shou, Anthony B. Firulli   +11 more
doaj   +1 more source