Results 91 to 100 of about 55,055 (299)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Bird populations as sentinels of endocrine disrupting chemicals

Annali dell'Istituto Superiore di Sanità, 2010
Exposure to endocrine disrupting chemicals (EDCs) is a widespread phenomenon in nature. Although the mechanisms of action of EDCs are actively studied, the consequences of endocrine disruption (ED) at the population level and the adaptations evolved to ...
Claudio Carere, David Costantini, Alberto Sorace, Daniela Santucci, Enrico Alleva   +4 more
doaj   +1 more source

Intersex related gene expression profiles in clams Scrobicularia plana : molecular markers and environmental application [PDF]

, 2015
Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K.
Alvarez-Munoz, Diana, Ciocan, Corina, Ciocan, Corina M., Cornelius, Keith, Cubero-Leon, Elena, Hill, E. M., Hill, Elizabeth, Indiveri, Paolo, Langston, William, Langston, William J., Lerebours, Adelaide, Minier, Christophe, Pope, Nick, Rotchell, Jeanette, Rotchell, Jeanette M.   +14 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Computational Study of Drugs Targeting Nuclear Receptors

Molecules, 2020
Endocrine-disrupting chemicals have been shown to interfere with the endocrine system function at the level of hormone synthesis, transport, metabolism, binding, action, and elimination. They are associated with several health problems in humans: obesity,
Maša Kenda, Marija Sollner Dolenc
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Relations of environmental contaminants, algal toxins, and diet with the reproductive success of American alligators on Florida Lakes [PDF]

, 2001
(113 page ...
Arnold, Beverly S., Gross, Timothy S., McDonald, Kelly, Spulveda, Maria S.   +3 more
core  

A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases

, 2018
Environmental contaminant exposure can pose significant risks to human health. Therefore, evaluating the impact of this exposure is of great importance; however, it is often difficult because both the molecular mechanism of disease and the mode of action
Iida, Midori, Takemoto, Kazuhiro
core   +1 more source

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source