Results 121 to 130 of about 174,481 (308)

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Exposure to per- and polyfluoroalkyl substances during fetal development and risk of testicular germ cell cancer in adulthood

Environment International
Background: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking.
Cecilie S. Uldbjerg, Youn-Hee Lim, Astrid L. Beck, Jørgen H. Petersen, Karina M. Sørensen, David M. Kristensen, Panu Rantakokko, Brent A. Coull, Christian Lindh, Niels E. Skakkebæk, Russ Hauser, Elvira V. Bräuner, Lærke Priskorn, Anders Juul   +13 more
doaj   +1 more source

Imposex in Plicopurpura pansa (Neogastropoda: Thaididae) in Nayarit and Sinaloa, Mexico

Revista Mexicana de Biodiversidad, 2015
Imposex is the development of male features in female prosobranch gastropods, caused by organotin compounds. In the Mexican Pacific coast, imposex was observed in Plicopurpura pansa.
Delia Domínguez-Ojeda, Olga Araceli Patrón-Soberano, José Trinidad Nieto-Navarro, María de Lourdes Robledo-Marenco, Jesús Bernardino Velázquez-Fernández   +4 more
doaj   +1 more source

Investigation of \u3cem\u3ede novo\u3c/em\u3e cholesterol synthetic capacity in the gonads of goldfish (\u3cem\u3eCarassius auratus\u3c/em\u3e) exposed to the phytosterol beta-sitosterol [PDF]

, 2006
Total and intra-mitochondrial gonadal cholesterol concentrations are decreased in fish exposed to the phytoestrogen beta-sitosterol (beta-sit). The present study examined the potential for beta-sit to disrupt de novo cholesterol synthesis in the gonads ...
Drolet, Melissa, MacLatchy, Deborah L., Sharpe, Rainie L.   +2 more
core   +1 more source

The intersection of neurotoxicology and endocrine disruption [PDF]

NeuroToxicology, 2012
Endocrine disruption, the guiding theme of the 27th International Neurotoxicology Conference, merged into the neurotoxicology agenda largely because hormones help steer the process of brain development. Although the disruption motif first attracted public health attention because of reproductive anomalies in both wildlife and humans, the ...
openaire   +2 more sources

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, EarlyView.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

A catchment-based study of endocrine disruption in surface waters: multivariate evaluation of the health of a sentinel fish species exposed to sewage treatment works effluent [PDF]

, 2009
Summary of the results in the context of EDCAT 5 project aims: 1. By comparing appropriate biomarkers in fish sampled from STW-impacted sites and control sites during the pre-remediation period, to determine whether there was evidence for any effects ...
Abel, David, Cook, Alastair, Juergens, Monika D., Katsiadaki, Ioanna, Pottinger, Tom G., Rhodes, Glenn, Sanders, Matthew   +6 more
core  

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source