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Environmental Endocrine Disrupters
Sexual Development, 2008Androgens, anti-Müllerian hormone, and insulin-like factor 3 are testis-derived hormones that regulate male sexual differentiation. Correct timing of secretion and action of these hormones is critical for normal development. Endocrine disrupters are exogenous substances that cause adverse effects in the endocrine system.
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Adrenocortical endocrine disruption
The Journal of Steroid Biochemistry and Molecular Biology, 2016The adrenal has been neglected in endocrine disruption regulatory testing strategy. The adrenal is a vital organ, adrenocortical insufficiency is recognised in life threatening "adrenal crises" and Addison's disease, and the consequences of off-target toxicological inhibition of adrenocortical steroidogenesis is well recognised in clinical medicine ...
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Endocrine Disruption and Hypospadias
2004The complexity of human biology makes it impossible to know for certain if endocrine disruption accounts for human penile deformities. Toxicologists point out that an overall assessment of risk must include other factors in addition to exposure including absorption, metabolism, excretion, bioaccumulation and other chemical interactions (Harrison et al.,
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Endocrine disrupters in the aquatic environment
Environmental Science and Pollution Research, 1997Possible mechanisms to explain endocrine effects on reproduction and sex differentiation are presented for selected pharmaceuticals, agrochemicals, industrial chemicals and plant sterols which are known to be present in the aquatic environment. Disruptions of the hormonal coordination can be induced by xenobiotics on various levels of the hierachically
P, Stahlschmidt-Allner +3 more
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Endocrine disrupting chemicals and bone
Best Practice & Research Clinical Endocrinology & Metabolism, 2021Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. EDCs exert their hormonal effects through several mechanisms; modulating hormone receptors or changing metabolism of different hormones.
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Endocrine Effects of Circadian Disruption
Annual Review of Physiology, 2016Disruption of circadian rhythms, provoked by artificial lighting at night, inconsistent sleep-wake schedules, and transmeridian air travel, is increasingly prevalent in modern society. Desynchrony of biological rhythms from environmental light cycles has dramatic consequences for human health.
Tracy A, Bedrosian +2 more
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Endocrine disrupters: A human risk?
Molecular and Cellular Endocrinology, 2005Endocrine disrupters (EDs) alter normal hormonal regulation and may be naturally occurring or environmental contaminants. Classically, EDs act genomically, with agonistic or antagonistic effects on steroid receptors and may alter reproductive function and/or cause feminisation by binding to oestrogen or androgen receptors; their binding to the thyroid ...
R H, Waring, R M, Harris
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Endocrine-disrupting chemicals
Best Practice & Research Clinical Endocrinology & Metabolism, 2021Wieland, Kiess, Gabriele, Haeusler
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2002
The first indications that hormonal imbalance during pregnancy may result in abnormal development of the fetus goes back to the 1930s. In 1939 researchers at Northwestern University Medical School reported that when pregnant rats were given an extra dose of external estrogen, the offspring suffered structural defects in their sex organs, both females ...
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The first indications that hormonal imbalance during pregnancy may result in abnormal development of the fetus goes back to the 1930s. In 1939 researchers at Northwestern University Medical School reported that when pregnant rats were given an extra dose of external estrogen, the offspring suffered structural defects in their sex organs, both females ...
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Endocrine disrupting chemicals
The Journal of Steroid Biochemistry and Molecular Biology, 2011Blumberg, Bruce +2 more
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