Results 31 to 40 of about 173,464 (288)

Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid

Environment International, 2022
Objective: To examine whether selected endocrine disrupting chemicals were present in pregnant women and passed through the placental barrier to amniotic fluid, potentially exposing the developing fetus.
Elvira V. Bräuner, Cecilie S. Uldbjerg, Youn-Hee Lim, Laura S. Gregersen, Marianna Krause, Hanne Frederiksen, Anna-Maria Andersson   +6 more
doaj   +1 more source

Impacts of in vivo and in vitro exposures to tamoxifen: comparative effects on human cells and marine organisms [PDF]

, 2019
Tamoxifen (TAM) is a first generation-SERM administered for hormone receptor-positive (HER+) breast cancer in both pre- and post-menopausal patients and may undergo metabolic activation in organisms that share similar receptors and thus face comparable ...
Abessa, D. M. S., Bebianno, M., Carriço, T., Fernandes, E., Fonseca, T. G., Tavares, A.   +5 more
core   +1 more source

Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model

Frontiers in Endocrinology, 2023
IntroductionAdministration of dexamethasone (DEX) has been used experimentally to suppress androgenization of external genitalia in 46,XX fetuses with congenital adrenal hyperplasia.
Cecilie Melau, Cecilie Melau, Berta Gayete Mor, Berta Gayete Mor, Malene Lundgaard Riis, Malene Lundgaard Riis, John E. Nielsen, John E. Nielsen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Lea Langhoff Thuesen, Kristine Juul Hare, Rod T. Mitchell, Hanne Frederiksen, Hanne Frederiksen, Anders Juul, Anders Juul, Anders Juul, Anne Jørgensen, Anne Jørgensen   +20 more
doaj   +1 more source

Deletion in the uridine diphosphate glucuronyltransferase 2B17 gene is associated with delayed pubarche in healthy boys

Endocrine Connections, 2018
Objective: Only a few genetic loci are known to be associated with male pubertal events. The ability of excreting testosterone (T) and other steroids in the urine depends on sulfation and glucuronidation.
Annette Mouritsen, Alexander Siegfried Busch, Lise Aksglaede, Ewa Rajpert-De Meyts, Anders Juul   +4 more
doaj   +1 more source

Reduced serum concentrations of biomarkers reflecting Leydig and Sertoli cell function in male patients with congenital adrenal hyperplasia

Endocrine Connections, 2023
Congenital adrenal hyperplasia (CAH) is a recessive condition t hat affects the adrenal glands. Despite life-long replacement therapy with glucocorticoids and mineralocorticoids, adult patients with CAH often experience impaired gonadal function.
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jørgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul   +11 more
doaj   +1 more source

Rapid bioconcentration of steroids in the plasma of three-spined stickleback Gasterosteus aculeatus exposed to waterborne testosterone and 17β-oestradiol [PDF]

, 2007
The relationship over time between the concentrations of two steroids, singly and in combination, in a static exposure system and in the blood of three-spined stickleback Gasterosteus aculeatus, held within the exposure system was investigated. Groups of
Matthiessen, P., Maunder, R. J., Pottinger, T. G., Sumpter, J. P.   +3 more
core   +1 more source

Endocrine disrupters as obesogens [PDF]

Molecular and Cellular Endocrinology, 2009
The recent dramatic rise in obesity rates is an alarming global health trend that consumes an ever increasing portion of health care budgets in Western countries. The root cause of obesity is thought to be a prolonged positive energy balance. Hence, the major focus of preventative programs for obesity has been to target overeating and inadequate ...
Felix, Grün, Bruce, Blumberg
openaire   +2 more sources

Environmental chemical exposures and breast cancer [PDF]

, 2016
As a hormone-sensitive condition with no single identifiable cause, breast cancer is a major health problem. It is characterized by a wide range of contributing factors and exposures occurring in different combinations and strengths across a lifetime ...
Plant, J, Stanley, E, Voulvoulis, N
core   +2 more sources

Butylated Hydroxyanisole (BHA) Disrupts Brain Signalling in Embryo–Larval Stage of Zebrafish Leading to Attention Deficit Hyperactivity Disorder (ADHD)

Journal of Xenobiotics
Background: Butylated hydroxyanisole (BHA) has been extensively used in several commercial industries as a preservative. It causes severe cellular and neurological damage affecting the developing fetus and might induce attention deficit hyperactivity ...
Kandhasamy Veshaal, Ramasamy Vasantharekha, Usha Rani Balu, Mahesh Vallabi Aayush, Saheshnu Sai Balaji Pillai, Winkins Santosh, Barathi Seetharaman   +6 more
doaj   +1 more source

Biochemical identification of prepubertal boys with Klinefelter syndrome by combined reproductive hormone profiling using machine learning

Endocrine Connections, 2023
Objective: Klinefelter syndrome (KS) is the most common sex chromosome disorder and genetic cause of infertility in males. A highly variable phenotype contributes to the fact that a large proportion of cases are never diagnosed.
Andre Madsen, Anders Juul, Lise Aksglaede   +2 more
doaj   +1 more source