Results 91 to 100 of about 1,301,264 (280)

Endocrine disruptor regulation of microRNA expression in breast carcinoma cells.

PLoS ONE, 2012
BackgroundSeveral environmental agents termed "endocrine disrupting compounds" or EDCs have been reported to bind and activate the estrogen receptor-α (ER). The EDCs DDT and BPA are ubiquitously present in the environment, and DDT and BPA levels in human
Syreeta L Tilghman, Melyssa R Bratton, H Chris Segar, Elizabeth C Martin, Lyndsay V Rhodes, Meng Li, John A McLachlan, Thomas E Wiese, Kenneth P Nephew, Matthew E Burow   +9 more
doaj   +1 more source

Diet-dependence of metabolic perturbations mediated by the endocrine disruptor tolylfluanid

Endocrine Connections, 2018
Emerging evidence implicates environmental endocrine-disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes; however, the interactions between EDCs and traditional risk factors in disease pathogenesis remain
Shane M Regnier, Andrew G Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan , Robert M Sargis   +6 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program.

ALTEX, 2014
In 1996, the U.S. Congress passed the Food Quality Protection Act and amended the Safe Drinking Water Act (SDWA) requiring the U.S. Environmental Protection Agency (EPA) to implement a screening program to investigate the potential of pesticide chemicals
D. Juberg, S. Borghoff, R. Becker, W. Casey, T. Hartung, M. Holsapple, M. S. Marty, E. Mihaich, G. J. Van Der Kraak, M. Wade, C. Willett, M. Andersen, C. Borgert, K. Coady, M. Dourson, J. Fowle, L. Gray, J. Lamb, L. Ortego, T. Schug, C. Toole, L. Zorrilla, Oliver L Kroner, J. Patterson, L. Rinckel, B. Jones   +25 more
semanticscholar   +1 more source

Impact of Endocrine Disrupting Pesticide Use on Obesity: A Systematic Review

Biomedicines
Background/Objectives: Endocrine disruptors are substances capable of altering the functions of the endocrine system. There is evidence that some pesticides can be endocrine disruptors and, among some of their effects, we find alterations in pubertal ...
Marcelino Pérez-Bermejo, Cristian Barrezueta-Aguilar, Javier Pérez-Murillo, Ignacio Ventura, María Ester Legidos-García, Francisco Tomás-Aguirre, Manuel Tejeda-Adell, Miriam Martínez-Peris, Belén Marí-Beltrán, María Teresa Murillo-Llorente   +9 more
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Preliminary studies on the occurrence of nonylphenol in the marine environments, Chennai—a case study

Journal of Basic and Applied Zoology, 2018
Background Resisting degradation, nonylphenol (NP) remains as a critical compound contaminating many habitats. Prevalence of nonylphenol in the ecosystem of Indian coastlines is not well documented as that of fresh water.
Subha Raju, Madhumathi Sivamurugan, Karuna Gunasagaran, Thirunavukkarasu Subramani, Munuswamy Natesan   +4 more
doaj   +1 more source

Designing Asymmetric Memristive Behavior in Proton Mixed Conductors for Neuromorphic Applications

Advanced Functional Materials, EarlyView.
Protonic devices that couple ionic and electronic transport are demonstrated as bioinspired neuromorphic elements. The devices exhibit rubber‐like asymmetric memristive behavior with slow voltage‐driven conductance increase and rapid relaxation, enabling simplified read–write operation.
Nada H. A. Besisa, Masaki Tsuji, Yoshihiro Furue, Yifan Geng, Satya P. Pati, Satoshi Hamasuna, Takeaki Yajima   +6 more
wiley   +1 more source