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The Impact of Endocrine Disruptors on Endocrine Targets
Endocrine disruption represents one of the most controversial environmental issues of our époque. So far, many substances, both natural and artificial, have been recognized to interfere with endocrine signaling pathways. In intact laboratory animals, this interaction has been documented to generate adverse health outcomes by impairing normal functions.
Diamanti-Kandarakis, E. +3 more
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Bisphenol A: An endocrine and metabolic disruptor
Bisphenol A (BPA), initially designed, like diethylstilbestrol, as a synthetic estrogen, has been rapidly and widely used for its cross-linking properties in the manufacture of polycarbonate plastics and epoxy resins. Because of incomplete polymerization and degradation of the polymers by exposure to higher than usual temperatures, BPA leaches out from
Fenichel, Patrick +2 more
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Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis
Endocrine disruptors (EDs) are chemical substances capable of affecting endocrine system functioning and interfering with organ morphogenesis and physiological functions. The development and regeneration of bone tissues have a complex hormonal regulation,
Ramona D’Amico +12 more
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Background: Per- and polyfluoroalkyl substances (PFAS) have raised significant health concerns. In 2019, drinking water source was changed due to PFAS contamination in the Tama region, Tokyo, Japan.
Zhaoqing Lyu +5 more
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Effects of Environmental Exposures on Fetal and Childhood Growth Trajectories
Delayed fetal growth and adverse birth outcomes are some of the greatest public health threats to this generation of children worldwide because these conditions are major determinants of mortality, morbidity, and disability in infancy and childhood and ...
Tongzhang Zheng +17 more
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Background: Endocrine-disrupting chemicals (EDCs) are widespread environmental contaminants that interfere with hormonal signaling and are associated with adverse reproductive, metabolic, thyroid, neurodevelopmental, and other endocrine-related health ...
Rossella Cannarella +3 more
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Endocrine-disrupting chemicals are a new class of pollutants that can affect hormonal metabolic processes in animals and humans. They can enter the aquatic environment through various pathways and gradually become enriched, thus posing a serious threat ...
Dong Liang +3 more
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ENDOCRINE DISRUPTORS AND PREGNANCY
Sensitivity to endocrine disruptors is higher in early life. In pregnant women, endocrine disruptor chemicals can be passed to the baby through the placenta or through breast milk during lactation, leading to long-term and permanent adverse effects. These endocrine disruptors may cause adverse effects in women such as infertility, implantation defects,
YİĞİT YALÇIN, Betül +2 more
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Homeostatic disruptor agents, and endocrine disruptor compounds (EDC) specifically, can originate from agricultural and industrial chemicals. If they modify the adaptation of living organisms as direct (e.g., by altering hormone regulation, membrane ...
Krisztián Sepp +8 more
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BackgroundEndocrine disruptor chemicals elicit adverse health effects by perturbing nuclear receptor signalling systems. It has been speculated that these compounds may also perturb epigenetic mechanisms and thus contribute to the early origin of adult ...
Alison M Anderson +3 more
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