Results 181 to 190 of about 35,443 (336)

Heavy metals as endocrine disruptors. [PDF]

Turk J Med Sci
Or Koca A.
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Integrative analysis of endocrine-disrupting chemical effects in the developing hypothalamus : adult behaviors and neural networks

, 2015
Viktoria Y. Topper
openalex   +1 more source

Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction. [PDF]

Front Behav Neurosci
Jocsak G, Kiss DS, Alymbaeva D, Diebald A, Zsarnovszky A, Heinzlmann A, Bartha T.   +6 more
europepmc   +1 more source

Endocrine disruptors - a current problem for the human body [PDF]

Introduction. Endocrine disruptors are chemical substances that cause adverse effects in an organism or its offspring, leading to morphological and physiological changes and contributing to the deterioration of functional capacities. In the human body,
Miron, Inga, Bernic, Vladimir, Zavtoni, Mariana, Corețchi, Roman   +3 more
core  

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Editorial: Further advances in understanding the endocrine cancer microenvironment

Frontiers in Endocrinology, 2022
Francesca Coperchini, Rosa Marina Melillo, Rosa Marina Melillo, Mario Rotondi, Mario Rotondi   +4 more
doaj   +1 more source

Endocrine disruptors, obesity, and metabolic syndrome. [PDF]

Turk J Med Sci
Barlas T, Eroğlu Altinova A, Coşkun M, Cerit ET.   +3 more
europepmc   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

The influence of endocrine disruptors on the gut microbiota. [PDF]

Turk J Med Sci
Uğur K.
europepmc   +1 more source