Results 51 to 60 of about 39,605 (275)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk [PDF]
, 2015 PURPOSE: We carried out a case-control study to investigate the possible role of occupational and environmental exposure to endocrine disruptors in the onset of testicular cancer (TC). METHODS: We evaluated 125 TC patients and 103 controls.
CATTARUZZA, Maria Sofia +7 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Exposure to polybrominated diphenyl ethers (PBDEs) suppresses the release of pro-inflammatory products by alveolar macrophages in vitro [PDF]
, 2010 Endocrine disrupting chemicals have adverse effects on immune function that may result in respiratory conditions. Inhalation of dust is a major route of exposure to PBDEs; however, the impact of PBDEs on the immune response is unclear.
Hennigar, Stephen R
core +1 more source
BPA-Induced Deregulation of Epigenetic Patterns: Effects on Female Zebrafish Reproduction [PDF]
, 2016 Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms.
Carnevali, Oliana +6 more
core +1 more source
Endocrine Disruptors and Testis Development [PDF]
Environmental Health Perspectives, 1998 There is currently much debate as to which in vivo tests should be selected for the detection of adverse effects of endocrine disruptors in test animals. As co-authors of a much-cited article in Environmental Health Perspectives. which described small (but significant) decreases in testicular weight of adult rats that had been exposed developmentally ...
Sharpe, RM, Turner, KJ, Sumpter, JP
openaire +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Mediators of Inflammation, 2016 CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit.
Mario Rotondi +8 more
doaj +1 more source
CHIMIA, 2008 The presence of hormonally active chemicals ('endocrine disruptors') in the biosphere has become a worldwide environmental concern. In 1999, a report released by the Swiss Federal Office for the Environment (FOEN) concluded that such chemicals ...
Felix R. Althaus
doaj +1 more source
New approaches for estimating risk from exposure to diethylstilbestrol. [PDF]
, 1999 A subgroup from a National Institute of Environmental Health Sciences, workshop concerned with characterizing the effects of endocrine disruptors on human health at environmental exposure levels considered the question, If diethylstilbestrol (DES) were ...
Cunha, GR +7 more
core +2 more sources