Results 71 to 80 of about 1,333,671 (322)

Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk [PDF]

, 2015
PURPOSE: We carried out a case-control study to investigate the possible role of occupational and environmental exposure to endocrine disruptors in the onset of testicular cancer (TC). METHODS: We evaluated 125 TC patients and 103 controls.
CATTARUZZA, Maria Sofia, F. Giannandrea, GANDINI, Loredana, LENZI, Andrea, LOMBARDO, Francesco, M. Gallo, PAOLI, Donatella, R. Turci   +7 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Endocrine disruptors in teleosts: Evaluating environmental risks and biomarkers

, 2020
Endocrine disruptors (EDs) are synthetic or natural chemical molecules occurring in environment that have the potential to impart adverse effects on homeostasis of endocrine axis leading to neurological, developmental, immunological and reproductive ...
Sonika Kar, Prabhaker Sangem, Narlagiri Anusha, B. Senthilkumaran   +3 more
semanticscholar   +1 more source

Advances in Electrochemical Impedance Spectroscopy Detection of Endocrine Disruptors

Italian National Conference on Sensors, 2020
Endocrine disruptors (EDs) are contaminants that may mimic or interfere with the body’s hormones, hampering the normal functions of the endocrine system in humans and animals.
Lucian-Gabriel Zamfir, M. Puiu, C. Bala
semanticscholar   +1 more source

Fate of drugs during wastewater treatment [PDF]

, 2013
This is the post-print version of the final paper published in TrAC Trends in Analytical Chemistry. The published article is available from the link below.
Andrási, Bagnall, Baker, Baker, Barceló, Bedding, Bernhard, Brodin, Bruce Petrie, Buisson, Carbonaro, Chen, Chiaia-Hernandez, Chiu, Clara, Coelho, Duan, Elise Cartmell, Ewan J. McAdam, Ferrer, Galus, Gardner, Gaulke, Gomes, Gomes, Gomes, Gong, Grabic, Gracia-Lor, Gros, Gros, Grover, Guibaud, Gunnarsson, Göbel, Hashimoto, Helbling, Hignite, Ho, Hoigne, Huber, Huber, Huntscha, Hörsing, Ifelebuegu, Jelic, John N. Lester, Jones, Jones, Jones, Jones, Joss, Kasprzyk-Hordern, Khunjar, Kim, Kimura, Kosjek, Kreuzinger, Langford, Lishman, López-Serna, López-Serna, Marchese, Mark D. Scrimshaw, Matamoros, Maurer, McAdam, Metcalfe, Nakada, Nakada, Nieto, Ort, Ort, Petrie, Radjenovic, Radjenović, Reungoat, Robertson, Rosal, Samaras, Schaar, Sebők, Shen, Silva, Snyder, Snyder, Sumpter, Ternes, Ternes, Urase, Vader, Wagner, Wu, Wunder, Yang, Zearley, Zhao, Zorita, Zuloaga   +98 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation

Mediators of Inflammation, 2016
CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit.
Mario Rotondi, Francesca Coperchini, Oriana Awwad, Patrizia Pignatti, Christian A. Di Buduo, Vittorio Abbonante, Flavia Magri, Alessandra Balduini, Luca Chiovato   +8 more
doaj   +1 more source

Endocrine Disruptors and Testis Development [PDF]

Environmental Health Perspectives, 1998
There is currently much debate as to which in vivo tests should be selected for the detection of adverse effects of endocrine disruptors in test animals. As co-authors of a much-cited article in Environmental Health Perspectives. which described small (but significant) decreases in testicular weight of adult rats that had been exposed developmentally ...
Sharpe, RM, Turner, KJ, Sumpter, JP
openaire   +4 more sources

The insulin-like growth factor system: A target for endocrine disruptors?

Environment International, 2020
The insulin-like growth factor (IGF) system is a critical regulator of growth, especially during fetal development, while also playing a central role in metabolic homeostasis.
C. Talia, L. Connolly, P. Fowler
semanticscholar   +1 more source

Exposure to polybrominated diphenyl ethers (PBDEs) suppresses the release of pro-inflammatory products by alveolar macrophages in vitro [PDF]

, 2010
Endocrine disrupting chemicals have adverse effects on immune function that may result in respiratory conditions. Inhalation of dust is a major route of exposure to PBDEs; however, the impact of PBDEs on the immune response is unclear.
Hennigar, Stephen R
core   +1 more source