Results 81 to 90 of about 317,844 (278)

Correction to: Impact of perinatal environmental health education intervention on exposure to endocrine disruptors during pregnancy—PREVED study: study protocol for a randomized controlled trial

Trials, 2021
Houria E. L. Ouazzani, Steeve Rouillon, Nicolas Venisse, Lynda Sifer-Rivière, Antoine Dupuis, Guillaume Cambien, Sarah Ayraud-Thevenot, Anne-Sophie Gourgues, Pascale Pierre-Eugène, Fabrice Pierre, Sylvie Rabouan, DisProSE Group, Virginie Migeot, Marion Albouy-Llaty   +13 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Comparison of the toxicokinetics of daidzein and bisphenol A in pregnant and non-pregnant DA/Han rats [PDF]

Potentially adverse human and environmental effects due to hormone mimicry of environmental estrogens are a matter of current concern. Environmental estrogens belong to the socalled endocrine active compounds (EAC) and may alter signalling processes of ...
Degen, Gisela H., Selinski, Silvia
core  

Estrogenic and androgenic activities in total plasma measured with reporter-gene bioassays: Relevant exposure measures for endocrine disruptors in epidemiologic studies?

Environment International, 2011
Measurements of estrogenic and androgenic activities in total plasma with Chemically Activated LUciferase gene eXpression (CALUX®) bioassays could provide biologically relevant measures for exposure to endocrine disruptors in epidemiologic studies.
Marijn M. Brouwers, Harrie Besselink, Reini W. Bretveld, Rob Anzion, Paul T.J. Scheepers, Abraham Brouwer, Nel Roeleveld   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Results of the Consensus Platforms: Positions and Recommendations Derived from Scientific Findings in a Joint Effort of Academics, Industry, and Authorities

CHIMIA, 2008
To convert scientific findings of the National Research Program (NRP) 'Endocrine Disruptors' into political and practical action the innovative tool of the consensus platforms has been created.
Marcel Trachsel
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The potential endocrine-disrupting of fluorinated pesticides and molecular mechanism of EDPs in cell models

Ecotoxicology and Environmental Safety
Environmental endocrine disruptors constitute a category of exogenous compounds that interfere with the endocrine system's functions in organisms or cells. As a class of particularly representative endocrine-disrupting chemicals, the accumulation of per-
Yalan Liu, Fengzhong Wang, Lin Li, Bei Fan, Zhiqiang Kong, Jianxin Tan, Minmin Li   +6 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

COMPRENDO: Focus and approach [PDF]

, 2006
Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife.
Wollenberger, L, Axel Allera, Vasilis Sakkas, Ronny van Aerle, Ballegoy, C., Gemma Janer, van Ballegoy, C, Sakkas, V., A. Allera, Isabella King, J. Falandysz, Christoph van Ballegoy, S. Galassi, Nicola Beresford, Aerle, R., Beresford, Nicola, K. O. Kusk, Hala, David, Janer, G, Kloas, W., Triantafyllos Albanis, Kusk, Kresten, Ole, Hala, D, F. Ciceri, Oredsson, Stina, Kusk, Kresten,, Oredsson, S., van Aerle, R., Galassi, S, Dagnac, T., Falandysz, Jerzy, Lo, S., Lutz, Ilka, Kingmüller, D., Werner Kloas, Albanis, T, Lutz, I., Stina Oredsson, Albanis, Triantafyllos, Klingmüller, Dietrich, van Ballegoy, C., Lund University., Wollenberger, L., Carnevali, Daniela, Candia, Carnevali, M. Daniela Candia, Susan Jobling, Levada, R, Kusk, Kresten Ole, Jobling, S., Oehlmann, Jörg, Ciceri, F, Jean Bachmann, M.D. Candia Carnevali, U. Schulte Oehlmann, Kusk, KO, Rand-Weaver, M., Lavado Parra, Ramón, Klingmüller, D., Schulte-Oehlmann, U., N. Beresford, Dagnac, T, D. Klingmüller, Aerle, Ronny van, Hala, D., King, I., P. Berntsson, Bachmann, J., R. Jeannot, Carnevali, Daniela Candia, Levada, R., Allera, A, Bachmann, J, Allera, A., Charles Tyler, Porte, C., Schulte-Oehlmann, Ulrike, Sakkas, Vasilis, Oredsson, Stina,, Sugni, M, Tyler, Charles R., Sakkas, M, Jeannot, R., Pia Berntsson, Marian Rand-Weaver, Ballegoy, Christoph van, Berntsson, P, Galassi, S., Kresten Ole Kusk, T. Albanis, Falandysz, J., Jörg Oehlmann, M SUGNI, R. Levada, Lutz, I, Falandysz, J, Porte, C, Ciceri, F., Janer, G., David Hala, Beresford, NA, Oredsson, S, Tyler, C., Kloas, W, Allera, Axel, T. Dagnac, Berntsson, Pia, Janer, Gemma, Schulte-Oehlmann, U, Michela Sugni, Carnevali, Daniela,, Tyler, C, Klingmüller, D, Beresford, N., Sakkas, V, Galassi, Silvana, Daniela Candia Carnevali, Francesca Ciceri, Dietrich Klingmüller, Lo, S, Beresford, N, Dagnac, Thierry, W. Kloas, Cinta Porte, Berntsson, Pia,, Albanis, T., Jobling, S, Jobling, Susan, King, Isabella, Van Aerle, Ronny, Kloas, Werner, Lo, Susan, Roger Jeannot, Wollenberger, Leah, D. Hala, Thierry Dagnac, Jerzy Falandysz, Oehlmann, J., J. Bachmann, Ulrike Schulte-Oehlmann, Bachmann, Jean, Sugni, M., Leah Wollenberger, Ramon Levada, Carnivali, D.C., Tyler, Charles, Berntsson, P., Silvana Galassi, S. Jobling, King, I, Sugni, Michela, Susan Lo, van Aerle, R, Ciceri, Francesca, Porte Visa, Cinta, G. Janer, Carnevali, DC, Rand-Weaver, Marian, Carnevali, D. C., Van Ballegoy, Christoph, Oehlmann, J, Levada, Ramon, Jeannot, Roger, Jeannot, R, Porte, Cinta, Kusk, K. O., Rand-Weaver, M, Ilka Lutz, I. King, Lutz I, Wollenberger L., Tyler C, Jobling S, Janer G, Albanis T, Carnevali DC, Hala D, Jeannot R, Oehlmann J, Falandysz J, Oredsson S, Klingmuller D, Allera A, Sakkas V, Porte C, Sugni M, van Aerle R, Dagnac T, Galassi S, Berntsson P, van Ballegoy C, Lo S, Kusk KO, Rand Weaver M, CICERI , FABIO, Bachmann J, Schulte Oehlmann U, Beresford N, King I, Levada R, Kloas W   +199 more
core   +1 more source