Results 81 to 90 of about 808,596 (294)

Midgut of Lepidopteran pupae is a major depot of sequestered, mobilizable, ecdysteroids

open access: yesMemorias do Instituto Oswaldo Cruz, 1987
Extirpation of endocrine organs - a classic maneuver in hormonal research - has been difficult or impossible in the case of the prothoracic glands (PG) of insects.
Carroll M. Williams
doaj   +1 more source

Natural Design of a Stabilized Cross‐β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats

open access: yesAdvanced Materials, EarlyView.
We report a 3.2 Å cryoEM structure of functional amyloid protein FapC from Pseudomonas sp. UK4, an essential component of bacterial biofilm, which reveals a Greek key‐shaped protofilament, supports bioinformatically determined motifs, nuances AlphaFold predictions, emphasizes heterogeneous cross‐β stacking in amyloid cross‐seeding and shows strain ...
Yanting Jiang   +13 more
wiley   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

open access: yesAdvanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania   +2 more
wiley   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

open access: yesAdvanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar   +7 more
wiley   +1 more source

The history of the parathyroid surgery

open access: yesRevista do Colégio Brasileiro de Cirurgiões
The authors conducted a review of the major aspects of progression of knowledge about the surgical treatment of hyperparathyroidism. Through literature review, we analyzed articles on the history of the evolution of anatomical, physiological ...
Marcelo Garcia Toneto   +4 more
doaj   +1 more source

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

open access: yesAdvanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni   +16 more
wiley   +1 more source

Hypopituarism - Not such an obvious symptom

open access: yesJournal of Education, Health and Sport
This paper presents the case of a diagnostic and therapeutic challenge of a young 33-year-old man from Poland, who initially reported few symptoms and eventually turned out to be an interesting endocrine case The pituitary gland is the central ...
Monika Grzybek   +9 more
doaj   +1 more source

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