Results 91 to 100 of about 466,117 (305)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Genomic hallmarks of endocrine therapy resistance in ER/PR+HER2- breast tumours

Communications Biology
ER/PR+HER2- breast tumours are the most predominant subtype of breast cancer worldwide, including India. Unlike TNBCs, these tumours can be treated with anti-estrogens or aromatase inhibitors.
Arnab Ghosh, Rohan Chaubal, Chitrarpita Das, Pallavi Parab, Subrata Das, Arindam Maitra, Partha P. Majumder, Sudeep Gupta, Nidhan K. Biswas   +8 more
doaj   +1 more source

Exploring the ER channel protein Sec61: recent advances in pathophysiological significance and novel pharmacological inhibitors

Frontiers in Pharmacology
The Sec61 complex, which is located on the membrane of the mammalian endoplasmic reticulum (ER), serves as a pivotal component of protein transport channels.
Jingxin Xin, Jingxin Xin, Jingxin Xin, Jingxin Xin, Jingxin Xin, Keling Yin, Keling Yin, Keling Yin, Keling Yin, Keling Yin, Shimeng Li, Shimeng Li, Shimeng Li, Shimeng Li, Shimeng Li, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao   +25 more
doaj   +1 more source

Treatment challenges in and outside a specialist network setting: Pancreatic neuroendocrine tumours [PDF]

, 2019
Pancreatic Neuroendocrine Neoplasms comprise a group of rare tumours with special biology, an often indolent behaviour and particular diagnostic and therapeutic requirements.
Almar E., Arveux P., Autelitano M., Baldi I., Bara S., Barchielli A., Benfatto L., Benhamou E., Bento M. J., Bielska-Lasota M., Blaszczyk J., Bordoni A., Botta L., Bouchardy C., Bouvier A. -M., Bouvier V., Brewster D. H., Calleja N., Candela P., Caplin M., Capocaccia R., Carulla M., Clough-Gorr K., Colonna M., Comber H., De Angelis R., de Lacerda G. F., de Munain A. L., Diaz Garcia J. M., Diba C. S., Dimitrova N., Dusek L., Engel J., Ess S. M., Falcini F., Falconi M., Ferretti S., Filiberti R. A., Fusai G. K., Fusco M., Galceran J., Gatta G., Gavin A., Gennaro V., Gentilini M., Giacomin A., Gozdz S., Grosclaude P., Guizard A. -V., Hackl M., Heidrich J., Henau K., Holleczek B., Huws D. W., Iannelli A., Johannesen T. B., Jonasson J. G., Kepska K., Knijn A., Konzelmann I., Kunkler I., Lapotre-Ledoux B., Larranaga N., Leinonen M., Luttmann S., Lykoudis P. M., Madeddu A., Magi M., Malila N., Mallone S., Mangone L., Marani E., Marcos-Gragera R., Maspero S., Maynadie M., Mazzoleni G., Michiara M., Miranda A., Molinie F., Monnereau A., Moreno-Iribas C., Mousavi M., Muffatti F., Navarro C., Nennecke A., Pannozzo F., Partelli S., Pierannunzio D., Piffer S., Pildava S., Primic-Zakelj M., Rachtan J., Rashbass J., Ricci P., Robaszkiewicz M., Rossi S., Rugge M., Salmeron D., Sanchez M. J., Santaquilani M., Sardo A. S., Schubert-Fritschle G., Schvartz C., Sekerija M., Sensi F., Serraino D., Smailyte G., Spagnoli G., Stabenow R., Stracci F., Tagliabue G., Tavilla A., Torrella-Ramos A., Trama A., Tretarre B., Troussard X., Tumino R., Usala M., Van Eycken E., Velten M., Visser O., Vitale F., Woronoff A. -S., Ziino A.   +123 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The role of surgery in the treatment of older women with breast cancer

, 2009
A significant proportion of women diagnosed with breast cancer are over the age of 70 years and there is evidence that these patients frequently do not receive standard treatments, including surgical procedures and adjuvant therapies, which would be ...
Audisio, R.A., Reed, M.W.R., Wyld, L.
core   +1 more source

Supersensitive PSA-Monitored neoadjuvant hormone treatment of clinically localized prostate cancer: Effects on positive margins, tumor detection and epithelial cells in bone marrow [PDF]

, 1998
Objective: The present study was done to investigate the effects of supersensitive PSA-controlled inductive treatment on positive margins, detection of tumor and epithelial cells in bone marrow of 101 patients with untreated and clinically localized ...
J. Kö, J. Spitz, K. Pantel, M. Kossiwakis, M.W. Kö, Th. Enzmann, U. Feek, U. Kaulfuss, W. Martell   +8 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Adherence to endocrine therapy among Chinese patients with breast cancer: current status and recommendations for improvement

Patient Preference and Adherence, 2018
Pin Gao,1 Lili You,2 Di Wu,1 Aiping Shi,1 Qing Miao,3 Ujala Rana,4 Dustin Paul Martin,3 Ye Du,1 Gang Zhao,1 Bing Han,1 Chao Zheng,5 Zhimin Fan1 1Department of Breast Surgery, First Hospital of Jilin University, Changchun, Jilin, China; 2Department of ...
Gao P, You L, Wu D, Shi A, Miao Q, Rana U, Martin DP, Du Y, Zhao G, Han B, Zheng C, Fan Z   +11 more
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