Results 81 to 90 of about 2,899,588 (264)

Research progress of resistance to aromatase inhibitor therapy in breast cancer

Zhongguo aizheng zazhi, 2021
Breast cancer is one of the most common malignancies in women. About 70% of patients are estrogen receptor (ER) and/or progesterone receptor (PR) positive.
李芷君, 徐兵河
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Genomic hallmarks of endocrine therapy resistance in ER/PR+HER2- breast tumours

Communications Biology
ER/PR+HER2- breast tumours are the most predominant subtype of breast cancer worldwide, including India. Unlike TNBCs, these tumours can be treated with anti-estrogens or aromatase inhibitors.
Arnab Ghosh, Rohan Chaubal, Chitrarpita Das, Pallavi Parab, Subrata Das, Arindam Maitra, Partha P. Majumder, Sudeep Gupta, Nidhan K. Biswas   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Exploring the ER channel protein Sec61: recent advances in pathophysiological significance and novel pharmacological inhibitors

Frontiers in Pharmacology
The Sec61 complex, which is located on the membrane of the mammalian endoplasmic reticulum (ER), serves as a pivotal component of protein transport channels.
Jingxin Xin, Jingxin Xin, Jingxin Xin, Jingxin Xin, Jingxin Xin, Keling Yin, Keling Yin, Keling Yin, Keling Yin, Keling Yin, Shimeng Li, Shimeng Li, Shimeng Li, Shimeng Li, Shimeng Li, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao   +25 more
doaj   +1 more source

Factors associated with cancer-related fatigue in breast cancer patients undergoing endocrine therapy in an urban setting: a cross-sectional study

BMC Cancer, 2010
Background Fatigue is prevalent in breast cancer survivors and has profound effects on daily life. The interference of fatigue with endocrine therapy may be difficult to separate.
Huang Xu, Zhang Qingyuan, Kang Xinmei, Song Ying, Zhao Wenhui   +4 more
doaj   +1 more source

Structural biology helps interpret variants of uncertain significance in genes causing endocrine and metabolic disorders [PDF]

, 2018
Context Variants of uncertain significance (VUSs) lack sufficient evidence, in terms of statistical power or experimental studies, to allow unequivocal determination of their damaging effect.
Sirawit Ittisoponpisan, David, A, Ittisoponpisan, Sirawit, Alessia David   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2001
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co-repressors,
Indarto, Dono, Izawa, Masao
core  

Urban-rural variations in quality-of-life in breast cancer survivors prescribed endocrine therapy [PDF]

, 2017
The number of breast cancer survivors has increased as a result of rising incidence and increased survival. Research has revealed significant urban–rural variation in clinical aspects of breast cancer but evidence in the area of survivorship is ...
Linda Sharp, Dombrowski, Stephan U, Thomas, Audrey Alforque, Stephan Dombrowski, Bennett, Kathleen E, Audrey Thomas, Caitriona Cahir, Cahir, Catriona, Kathleen Bennett, Sharp, Linda   +9 more
core   +1 more source