Results 61 to 70 of about 2,899,588 (264)

Current Status of Extended Adjuvant Endocrine Therapy in Early Stage Breast Cancer

, 2018
In the past decade, several endocrine treatment regimens have been developed for the adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer, including tamoxifen, aromatase inhibitors (AI), or a combination of these.
Sandra M. E. Geurts, van Hellemond, Irene E. G., Vivianne C. G. Tjan-Heijnen, Geurts, Sandra M. E., Tjan-Heijnen, Vivianne C. G., Irene E. G. van Hellemond   +5 more
core   +1 more source

Endocrine disruption in juvenile roach from English rivers: A preliminary study [PDF]

, 2004
Juvenile roach Rutilus rutilus from seven rivers of varying water quality were examined for evidence of endocrine disruption. The majority of roach from five of these rivers had femalelike reproductive ducts.
Williams, R, Sumpter, JP, Beresford, NA, Jobling, S   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Navigation through inter- and intratumoral heterogeneity of endocrine resistance mechanisms in breast cancer: A potential role for Liquid Biopsies?

Tumor Biology, 2017
The majority of breast cancers are hormone receptor positive due to the expression of the estrogen and/or progesterone receptors. Endocrine therapy is a major treatment option for all disease stages of hormone receptor–positive breast cancer and improves
Florian Reinhardt, André Franken, Tanja Fehm, Hans Neubauer   +3 more
doaj   +1 more source

Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy [PDF]

, 2019
The importance and role of the estrogen receptor (ER) pathway has been well-documented in both breast cancer (BC) development and progression. The treatment of choice in women with metastatic breast cancer (MBC) is classically divided into a variety of ...
Aradhana Rani (529007), Justin Stebbing, Giamas, G., Murphy, J.J., Justin Stebbing (181883), Georgios Giamas (4466365), Rani, A., John Murphy (1978417), Georgios Giamas, John Murphy, Stebbing, J., Aradhana Rani   +11 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evaluation of First-Line Endocrine Therapy for HR+/HER2- Metastatic Breast Cancer: Efficacy, Tolerance and Prescribing Practices. A Prospective and Observational study. [PDF]

Batna Journal of Medical Sciences
Introduction: Endocrine therapy is commonly employed for MBC (Metastatic Breast Cancer) patients due to its efficacy in modulating hormone receptors and its generally favorable side effect profile.
Asma BOUDERSA, Nassima KOUADRI, Taha FILALI   +2 more
doaj   +1 more source

Endocrine therapy in epithelial ovarian cancer [PDF]

, 2016
INTRODUCTION: The estrogen receptor (ER) is expressed at high levels in many epithelial ovarian cancers (EOC) and represents a potential target for endocrine therapy.
Langdon, SP, Gabra, H, Stanley, Barbara, Gourley, C, Langdon, Simon, Gourley, Charles, Stanley, B, Gabra, Hani   +7 more
core   +1 more source

Endocrine Late Effects in Childhood Cancer Survivors

, 2022
SIMPLE SUMMARY: Recent advances in cancer treatment have led to improved survival, with an exponential increase in sequelae among survivors. Around 50% of survivors will experience at least one hormonal disorder, with radiotherapy, hematopoietic stem ...
Paula Casano-Sancho, Ana Carolina Izurieta-Pacheco, Casano-Sancho, Paula, Izurieta-Pacheco, Ana Carolina   +3 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source