Results 51 to 60 of about 2,899,588 (264)

Severe hyperlipidemia pancreatitis induced by taking tamoxifen after breast cancer surgery—Case report

Frontiers in Oncology, 2023
IntroductionThe research investigates the mechanism, diagnosis, treatment, and subsequent endocrine therapy of severe pancreatitis induced by tamoxifen treatment in patients who have undergone breast cancer surgery.Case presentationWe studied two cases ...
Chao Zhai, Xiang Li, Dong Xiao, Liang Chen, Chaoyang Wang, MingHua Zheng   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET) [PDF]

Background: This study reports the detailed management and outcomes of women treated with Primary Endocrine Therapy (PET) in a large prospective UK cohort of older women (≥70) with breast cancer.
Audisio, Riccardo, Reed, M., Walters, Stephen, Wyld, Lynda, Wyld, L., Hubbard, Thomas, Wright, Georgia, Morgan, J., Cheung, Kwok-Leung, Audisio, R., Reed, Malcolm, Hubbard, T., Martin, C., Cheung, K. L., Walters, S., Wright, G., Morgan, Jenna, Martin, Charlene   +17 more
core   +1 more source

Preoperative Endocrine Therapy [PDF]

, 2017
Purpose of Review: Pre-operative endocrine therapy can be used to down-stage large or locally advanced breast cancers in ER+ disease. In the last four decades, it has evolved from a treatment perceived as an alternative to surgery for those too unfit to ...
J. Michael Dixon, Lucy R. Khan, Khan, Lucy R, Turnbull, Arran K, Dixon, J Michael, Arthur, Laura M, Laura M. Arthur, Arran K. Turnbull   +7 more
core   +1 more source

Human epidermal growth factor receptor-2 and endocrine resistance in hormone-dependent breast cancer

, 2022
Endocrine therapies are the main treatment strategies for the clinical management of hormone-dependent breast cancer. Despite prolonged time to recurrence in the adjuvant setting and the initial clinical responses in the metastatic setting, many patients
Dowsett, Mitch, Dowsett, M, Alataki, Anastasia, Alataki, A   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT

Programme Grants for Applied Research, 2022
Background: In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit.
Lynda Wyld, Malcolm WR Reed, Karen Collins, Sue Ward, Geoff Holmes, Jenna Morgan, Mike Bradburn, Stephen Walters, Maria Burton, Kate Lifford, Adrian Edwards, Kate Brain, Alistair Ring, Esther Herbert, Thompson G Robinson, Charlene Martin, Tim Chater, Kirsty Pemberton, Anne Shrestha, Anthony Nettleship, Paul Richards, Alan Brennan, Kwok Leung Cheung, Annaliza Todd, Helena Harder, Riccardo Audisio, Nicolo Matteo Luca Battisti, Juliet Wright, Richard Simcock, Christopher Murray, Alastair M Thompson, Margot Gosney, Matthew Hatton, Fiona Armitage, Julietta Patnick, Tracy Green, Deirdre Revill, Jacqui Gath, Kieran Horgan, Chris Holcombe, Matt Winter, Jay Naik, Rishi Parmeshwar   +42 more
doaj   +1 more source

Allosteric Modulators of Steroid Hormone Receptors : Structural Dynamics and Gene Regulation [PDF]

, 2012
Peer ...
McEwan, Iain J, Kumar, Raj
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Insights from a multi-institutional registry show duration of endocrine treatment for DCIS impacts second events

npj Breast Cancer
Ductal carcinoma in situ (DCIS) incidence has risen rapidly with the introduction of screening mammography, yet it is unclear who benefits from both the amount and type of adjuvant treatment (radiation therapy, endocrine therapy) versus what constitutes ...
Thomas J. O’Keefe, Christina Yau, Emma Iaconetti, Eliza Jeong, Case Brabham, Paul Kim, Joseph McGuire, Ann Griffin, Anne M. Wallace, Laura J. Esserman, Olivier Harismendy, Gillian L. Hirst   +11 more
doaj   +1 more source