Results 11 to 20 of about 255,642 (262)

Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer

Cancer Cell International, 2021
Drug resistance is always a great obstacle in any endocrine therapy of breast cancer. Although the combination of endocrine therapy and targeted therapy has been shown to significantly improve prognosis, refractory endocrine resistance is still common ...
Jing Chen, Runlan Wan, Qinqin Li, Zhenghuan Rao, Yanlin Wang, Lei Zhang, Alexander Tobias Teichmann   +6 more
doaj   +1 more source

Improvement of Pig Islet Function by In Vivo Pancreatic Tissue Remodeling: A “Human-Like” Pig Islet Structure with Streptozotocin Treatment

Cell Transplantation, 2013
Pig islets demonstrate significantly lower insulin secretion after glucose stimulation than human islets (stimulation index of ~12 vs. 2 for glucose 1 and 15 mM, respectively) due to a major difference in β- and α-cell composition in islets (60% and 25 ...
Sophie Vériter, Najima Aouassar, Gwen Beaurin, Rose-Marie Goebbels, Pierre Gianello, Denis Dufrane Ph.D.   +5 more
doaj   +1 more source

Overall survival and progression-free survival with endocrine therapy for hormone receptor-positive, HER2-negative advanced breast cancer: review

Therapeutic Advances in Medical Oncology, 2017
We reviewed randomized phase II/III trials comparing first- or second-line endocrine therapy as monotherapy or in combination with targeted therapies for treatment of postmenopausal patients with hormone receptor-positive advanced breast cancer.
Tomás Reinert, Carlos H. Barrios
doaj   +1 more source

Underlying mechanisms of glucocorticoid-induced β-cell death and dysfunction: a new role for glycogen synthase kinase 3

Cell Death and Disease, 2021
Glucocorticoids (GCs) are widely prescribed for their anti-inflammatory and immunosuppressive properties as a treatment for a variety of diseases. The use of GCs is associated with important side effects, including diabetogenic effects.
Etienne Delangre, Junjun Liu, Stefania Tolu, Kamel Maouche, Mathieu Armanet, Pierre Cattan, Gaëlle Pommier, Danielle Bailbé, Jamileh Movassat   +8 more
doaj   +1 more source

Notch Signaling Pathway and Endocrine Resistance in Breast Cancer

Frontiers in Pharmacology, 2020
Nearly 70% of breast cancers express the estrogen receptor (ER) and are hormone-dependent for cell proliferation and survival. Anti-estrogen therapies with aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs) or selective estrogen ...
Jing-Wen Bai, Jing-Wen Bai, Min Wei, Min Wei, Ji-Wei Li, Guo-Jun Zhang, Guo-Jun Zhang   +6 more
doaj   +1 more source

p53 Mutation as Plausible Predictor for Endocrine Resistance Therapy in Luminal Breast Cancer [version 2; peer review: 2 approved]

F1000Research, 2022
Endocrine therapy resistance in Luminal Breast Cancer is a significant issue to be tackled, but currently, no specific biomarker could be used to anticipate this event.
Yohana Azhar, Freda Halim, Bethy Hernowo, Suwarman Suwarman   +3 more
doaj   +1 more source

The research progress of endocrine therapy combined with targeted therapy for triple-positive breast cancer [PDF]

Zhongguo aizheng zazhi, 2023
Triple-positive breast cancer (TPBC) refers to breast cancer with positive expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2), accounting for 5%-10% of all pathological types of breast cancer.
CAO Xiaoshan, CONG Binbin
doaj   +1 more source

Perceptions of Endocrine Therapy in African-American Breast Cancer Survivors: Mixed Methods Study

JMIR Formative Research, 2021
BackgroundAlthough the incidence of breast cancer is lower in African-American women than in White women, African-American women have a decreased survival rate.
Donevant, Sara, Heiney, Sue P, Wineglass, Cassandra, Schooley, Benjamin, Singh, Akanksha, Sheng, Jingxi   +5 more
doaj   +1 more source

Association between Endocrine Therapy and Weight Gain after Breast Cancer Diagnosis among Japanese Patients: A Retrospective Cohort Study

Medical Sciences, 2021
Background: This study aimed to investigate the association between endocrine therapy and weight gain with a history of breast cancer. Methods: This was a retrospective cohort study.
Koki Okumatsu, Hideko Yamauchi, Rina Kotake, Masahiko Gosho, Yoshio Nakata   +4 more
doaj   +1 more source

A Randomized Trial Comparing Concurrent versus Sequential Radiation and Endocrine Therapy in Early-Stage, Hormone-Responsive Breast Cancer

Current Oncology
Concerns exist regarding increased toxicities, including endocrine therapy toxicity, with concurrent radiation and endocrine therapy in early breast cancer (EBC).
Sharon F. McGee, Mark Clemons, Gregory Pond, Jean-Michel Caudrelier, Michelle Liu, Mashari Jemaan Alzahrani, Terry L. Ng, Arif A. Awan, Sandeep Sehdev, John Hilton, Marie-France Savard, Lesley Fallowfield, Vikaash Kumar, Orit Freedman, Lisa Vandermeer, Brian Hutton, Jean-Marc Bourque   +16 more
doaj   +1 more source