Results 231 to 240 of about 466,117 (305)

Response to the letter "Targeted digital intervention boosts endocrine therapy adherence in breast cancer patients with low health literacy". [PDF]

Breast
Graetz I.
europepmc   +1 more source

Optimizing endocrine therapy

This thesis explored the pharmacokinetics of two important (classes of) drugs in the treatment of estrogen-receptor positive breast cancer: tamoxifen and CDK4/6 inhibitors. We investigated how the pharmacokinetics of these drugs relate to adverse effects and efficacy.
openaire   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Comparative Efficacy of Neoadjuvant Endocrine Therapy, Neoadjuvant Chemotherapy, and Neoadjuvant Chemo-Endocrine Therapy in Estrogen Receptor-Positive Breast Cancer Patients: A Meta-Analysis. [PDF]

Breast J
Yuan Y, Cui N, Xu Z, Cui C, Zhou Z, Ma Z.   +5 more
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Improving outcomeS for Women diagnosed with early breast cancer through adhErence to adjuvant Endocrine Therapy (SWEET): study protocol for a pragmatic randomised control trial of a patient-centred intervention to improve adherence to endocrine therapy in early breast cancer. [PDF]

Trials
McGeagh L, Walker A, Hiller L, Dunn J, Wells M, Donnelly P, Wardley A, Wolstenholme J, Horne R, Stewart SJ, Brett J, Cahir C, Fenlon D, Rose J, Turner L, Hughes L, Todd A, Nicholson B, Mawson P, Norris R, Thompson S, Dakin H, Barrows R, Kum S, Turner M, Rehman F, Cain H, Watson E, Sharp L, SWEET Research Team.   +29 more
europepmc   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Prognostic Significance of Pretreatment ¹⁸F-FDG PET/CT Parameters in Patients With ER+/HER2- Metastatic Breast Cancer Treated With CDK4/6 Inhibitors Plus Endocrine Therapy. [PDF]

Korean J Radiol
Suh M, Ryu J, Song H, Jeong JH, Han S, Jeong H, Kim JE, Shin Y, Jeong BK, Lee HJ, Gong G, Ahn JH, Jung KH, Kim SB, Moon DH.   +14 more
europepmc   +1 more source

Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets [PDF]

, 2018
et al,, Li, Shunqiang, Shao, Jieya
core   +1 more source