Results 241 to 250 of about 466,117 (305)

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Assessment of Adjuvant Endocrine Therapy With Ovarian Function Suppression by Breast Cancer Index.

JAMA Netw Open
O'Regan RM, Ren Y, Zhang Y, Siuliukina N, Schnabel CA, Kammler R, Viale G, Dell'Orto P, Munzone E, Láng I, Tondini C, Gomez HL, Chini C, Nicoletti SVL, Puglisi F, Zaman K, Goetz MP, Stearns V, Martino S, Salim M, Loibl S, Geyer CE, Bonnefoi HR, Ciruelos EM, Loi S, Colleoni M, Fleming GF, Francis PA, Walley BA, Pagani O, Treuner K, Regan MM.   +31 more
europepmc   +1 more source

Change in mammographic density as a potential predictor of cancer recurrence after breast conservation surgery and adjuvant endocrine therapy: results of the MEDICI study. [PDF]

Breast Cancer Res
Savaridas SL, Marshall A, Ali K, Astley SM, Evans AJ, Halling-Brown M, Vinnicombe S, Warwick VR, Whelehan P, Drummond S, Ebsim R, Healy NA, Nash J, Muscat E, Muthyala S, Sharma A, Telesca M, Dunn J.   +17 more
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Inadequate ovarian function suppression and endocrine therapy manipulations in premenopausal patients with early breast cancer on adjuvant LHRH agonist and aromatase inhibitor: a cohort study. [PDF]

ESMO Open
Valenza C, Etessami JD, Milano M, Papadopoulos N, Alvino M, Antonarelli G, Bianco N, Sangalli C, Trapani D, Pravettoni G, Omodeo Salè E, Passerini R, Colleoni M, Munzone E, Curigliano G.   +14 more
europepmc   +1 more source

Extended endocrine therapy use and decision making after breast cancer diagnosis. [PDF]

J Natl Cancer Inst
Kurian AW, Furgal AKC, Radhakrishnan A, Veenstra CM, Abrahamse P, Ward KC, Hamilton AS, Hofer TP, Katz SJ, Wallner LP, Hawley ST.   +10 more
europepmc   +1 more source

Remarkable response to CDK4/6 inhibitor-based endocrine therapy in HR+/HER2- metastatic male breast cancer with visceral crisis: a case report. [PDF]

Front Oncol
Liu J, Chen W, Wang J, Wang X.
europepmc   +1 more source

Ribociclib plus endocrine therapy in bone marrow visceral crisis: challenging the chemotherapy paradigm in luminal metastatic breast cancer-a case report. [PDF]

Front Oncol
Pérez-López OI, Lendinez-Sanchez G, González-García J, Jiménez-Rodríguez B, Leon-Fradejas M, Fernandez-Garay D.   +5 more
europepmc   +1 more source

Ninety Days of Preoperative Endocrine Therapy Informs Patient and Physician Preference for Radiation Therapy: Primary Results from the Preoperative Window of Endocrine Therapy to Inform Radiation Therapy Decisions (POWER) Trial. [PDF]

Ann Surg Oncol
Millard T, Turkheimer LM, Petroni G, Brighton D, Meneveau MO, Obidike P, McGuire K, Showalter SL.   +7 more
europepmc   +1 more source

Adjuvant Radiation and Endocrine Therapy in Early-Stage Breast Cancer With Low Genomic Risk.

JAMA Netw Open
Miller DG, Boe LA, Wen HY, Mueller B, Cuaron JJ, Choi JI, Bernstein MB, McCormick B, Powell SN, Khan AJ, Braunstein LZ.   +10 more
europepmc   +1 more source