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Which people with diabetes are treated with a disposable, half‐unit insulin pen? A real‐world, retrospective, database study in Spain

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 6, November 2023., 2023
Insulin lispro 100 units/mL Jr KwikPen® is the first insulin lispro 100 units/mL prefilled, disposable, half‐unit insulin pen that delivers 0.5–30 units in steps of 0.5 units for the treatment of Type 1 diabetes (T1D) and Type 2 diabetes (T2D). This study used electronic medical records to study the profile of patients with T1D and T2D in Spain who ...
F. Javier Ampudia‐Blasco +8 more
wiley +1 more source

Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity

BioFactors, Volume 49, Issue 4, Page 820-830, July/August 2023., 2023
We found puberty to be characterized by better inflammatory and oxidative control, as reflected by lower levels of C‐reactive protein and oxidative damage markers, as well as improved antioxidant defense. This was in turn accompanied by a healthier multielemental profile, with increased levels of essential elements involved in the antioxidant system ...
Álvaro González‐Domínguez +5 more
wiley +1 more source

Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones

BioFactors, Volume 49, Issue 4, Page 849-860, July/August 2023., 2023
Children with obesity, regardless of sex and insulin resistance status, showed elevated plasma copper‐to‐zinc ratios. In contrast, obesity‐related erythroid metal alterations were interestingly found to be sex‐dependent, with increased contents of iron, zinc, and copper being exclusively detected among female subjects.
Álvaro González‐Domínguez +4 more
wiley +1 more source

Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop

Journal of Bone and Mineral Research, Volume 37, Issue 12, Page 2568-2585, December 2022., 2022
ABSTRACT This clinical practice guideline addresses the prevention, diagnosis, and management of hypoparathyroidism (HypoPT) and provides evidence‐based recommendations. The HypoPT task forces included four teams with a total of 50 international experts including representatives from the sponsoring societies. A methodologist (GG) and his team supported
Aliya A. Khan +10 more
wiley +1 more source

Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight/obesity

Diabetes/Metabolism Research and Reviews, Volume 38, Issue 7, October 2022., 2022
Abstract Aims To compare the association of high serum uric acid (HUA) or metabolic syndrome (MetS) with fatty liver disease (FLD) in youths with overweight/obesity (OW/OB). Materials and Methods Cross‐sectional study of anthropometrics, biochemical variables, and liver ultrasound of 3104 individuals with OW/OB (age 5–17 years).
Procolo Di Bonito +10 more
wiley +1 more source

CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

Clinical Genetics, Volume 101, Issue 5-6, Page 481-493, May-June 2022., 2022
Abstract CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in ...
Juan Luque +371 more
wiley +1 more source

Copy number variations residing outside the SHOX enhancer region are involved in Short Stature and Léri‐Weill dyschondrosteosis

Molecular Genetics &Genomic Medicine, Volume 10, Issue 1, January 2022., 2022
The characterization of deletions identified in Short Staure patients through fine tiling aCGH narrowed down a critical interval downstream the enhancer that might contains elements relevant for SHOX expression. To identify undisclosed Abstract Background SHOX enhancer CNVs, affecting one or more of the seven recognized evolutionary conserved non ...
Antonella Fanelli +11 more
wiley +1 more source

Noonan syndrome: genetic and clinical update and treatment options

Anales de Pediatría (English Edition), 2020
Noonan syndrome (NS) is a relatively common genetic condition characterised by short stature, congenital heart defects, and distinctive facial features.NS and other clinically overlapping conditions such as NS with multiple lentigines (formerly called ...
Atilano Carcavilla +8 more
doaj +1 more source

Pancreatitis severa como manifestación inicial de adenoma parairoideo en pediatría

Revista Mexicana de Endocrinología, Metabolismo y Nutrición, 2021
El hiperparatiroidismo primario (HPTP) es una enfermedad poco prevalente en la edad pediátrica, cuya principal causa es la presencia de un adenoma paratiroideo solitario, seguido en frecuencia por la hiperplasia multiglandular y en casos extremadamente ...
Eulalia P. Garrido-Magaña +6 more
doaj +1 more source

Hipotiroidismo subclínico en niños y adolescentes: su importancia

Ciencia y Salud, 2018
El Hipotiroidismo Subclínico (HSC) es una afección frecuente en edades pediátricas. El objetivo de este trabajo es presentar una revisión de los estudios realizados en los últimos años.
Francisco Carvajal Martínez +4 more
doaj +1 more source

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