Results 131 to 140 of about 766,585 (300)

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Mind the gap: Adherence to denosumab dosing and cessation guidelines in Australian residential aged care

British Journal of Clinical Pharmacology, EarlyView.
This original research used medication administration data to explore adherence to treatment guidelines for the most common osteoporosis medications in long‐term residential aged care (RAC) in Australia. The paper highlights gaps in adherence to treatment guidelines that must be addressed to improve outcomes of older adults living in RAC.
Marea O'Donnell, Johanna I. Westbrook, Bayzidur Rahman, Isabelle Meulenbroeks, Nasir Wabe, Ian D. Cameron, Mark Morgan, Magdalena Z. Raban   +7 more
wiley   +1 more source

Reproductive endocrinology [PDF]

Human Reproduction, 2012
A. Nazzaro, A. Salerno, L. Di Iorio, G. Landino, S. Marino, E. Pastore, F. Fabregues, A. Iraola, G. Casals, M. Creus, S. Peralta, J. Penarrubia, D. Manau, S. Civico, J. Balasch, I. Lindgren, Y. L. Giwercman, E. Celik, I. Turkcuoglu, B. Ata, A. Karaer, P. Kirici, B. Berker, J. Park, J. Kim, J. Rhee, M. Krishnan, O. Rustamov, R. Russel, C. Fitzgerald, S. Roberts, S. Hapuarachi, B. K. Tan, R. S. Mathur, A. van de Vijver, C. Blockeel, M. Camus, N. Polyzos, L. Van Landuyt, H. Tournaye, N. O. Turhan, D. Hizli, Z. Kamalak, A. Kosus, N. Kosus, H. Kafali, A. Lukaszuk, M. Kunicki, J. Liss, A. Bednarowska, G. Jakiel, K. Lukaszuk, M. Lukaszuk, B. Olszak-Sokolowska, K. Lukaszuk, M. Kunicki, J. Liss, G. Jakiel, A. Bednarowska, T. Wasniewski, M. Neuberg, M. Lukaszuk, V. Cavalcanti, C. Peluso, B. L. Lechado, E. B. Cordts, D. M. Christofolini, C. P. Barbosa, B. Bianco, C. A. Venetis, E. M. Kolibianakis, J. Bosdou, B. C. Tarlatzis, M. Onal, D. N. Gungor, M. Acet, S. Kahraman, E. Kuijper, J. Twisk, M. Caanen, T. Korsen, P. Hompes, M. Kushnir, A. Rockwood, W. Meikle, C. B. Lambalk, D. Hizli, Z. Kamalak, A. Kosus, N. Kosus, N. O. Turhan, H. Kafali, X. Yan, X. Dai, J. Wang, N. Zhao, Y. Cui, J. Liu, F. Yarde, A. H. E. M. Maas, A. Franx, M. J. C. Eijkemans, J. T. Drost, B. B. van Rijn, J. van Eyck, Y. T. van der Schouw, F. J. M. Broekmans, F. Martyn, B. Anglim, M. Wingfield, T. Fang, G. J. Yan, H. X. Sun, Y. L. Hu, J. Chrudimska, P. Krenkova, M. Macek, M. Macek, J. Teixeira da Silva, M. Cunha, J. Silva, P. Viana, A. Goncalves, N. Barros, C. Oliveira, M. Sousa, A. Barros, S. M. Nelson, S. M. Lloyd, A. McConnachie, A. Khader, R. Fleming, D. A. Lawlor, L. Thuesen, A. N. Andersen, A. Loft, J. Smitz, M. Abdel-Rahman, S. Ismail, J. Silk, M. Abdellah, A. H. Abdellah, F. Ruiz, M. Cruz, M. Piro, D. Collado, J. A. Garcia-Velasco, A. Requena, Z. Kollmann, N. A. Bersinger, B. McKinnon, S. Schneider, M. D. Mueller, M. von Wolff, A. Vaucher, Z. Kollmann, N. A. Bersinger, B. Weiss, P. Stute, U. Marti, M. von Wolff, J. Chai, W. Y. T. Yeung, C. Y. V. Lee, W. H. R. Li, P. C. Ho, H. Y. E. Ng, S. M. Kim, S. H. Kim, B. C. Jee, S. Ku, C. S. Suh, Y. M. Choi, J. G. Kim, S. Y. Moon, J. H. Lee, S. G. Kim, Y. Y. Kim, H. J. Kim, K. H. Lee, I. H. Park, H. G. Sun, Y. I. Hwang, N. Y. Sung, M. H. Choi, S. H. Cha, C. W. Park, J. Y. Kim, K. M. Yang, I. O. Song, M. K. Koong, I. S. Kang, H. O. Kim, C. Haines, W. Y. Wong, W. S. Kong, L. P. Cheung, T. K. Choy, P. C. Leung, R. Fadini, T. W. Kelsey, I. Sfontouris   +201 more
openaire   +1 more source

Advanced therapy medicinal products (ATMPs) – An analysis of the global regulatory status

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background A rapid progress in the development of advanced therapy medicinal products (ATMPs) has taken place over the past decades. The ATMPs hold great potential but face challenges in the clinical development and the regulatory process.
Allan Cramer, Freja Karuna Hemmingsen Sørup, Marie Lund, Tonny Studsgaard Petersen, Kristian Karstoft   +4 more
wiley   +1 more source

Retracted: Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy

International Journal of Endocrinology, 2020
International Journal of Endocrinology
doaj   +1 more source

Lifespan Pancreas Morphology for Control Versus Type 2 Diabetes Using AI on Largescale Clinical Imaging

Clinical Anatomy, EarlyView.
ABSTRACT Understanding how pancreas size and shape change with normal aging is critical for establishing a baseline to detect deviations in type 2 diabetes and other pancreatic disease. We measure pancreas size and shape using morphological measurements from early development through aging (ages 0–90).
Lucas W. Remedios, Chloe Cho, Trent M. Schwartz, Dingjie Su, Gaurav Rudravaram, Chenyu Gao, Aravind R. Krishnan, Adam M. Saunders, Michael E. Kim, Shunxing Bao, Thomas A. Lasko, Alvin C. Powers, Bennett A. Landman, John Virostko   +13 more
wiley   +1 more source

Effect of serum anti‐Müllerian hormone levels on the superovulation response in Holstein heifers

Veterinary Medicine and Science
Background Anti‐Müllerian hormone (AMH) holds potential as a biomarker for assessing the superovulation (SO) response in cattle. Nonetheless, there exists scant information regarding this aspect in the literature concerning dairy heifers. Given this gap,
Mehmet Yildiz, Ilktan Bastan, Sohret Guler, Yunus Cetin   +3 more
doaj   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Pediatric Neuropalliative Medicine Clinic: Five‐Year Data Characterizing a Novel Model of Outpatient Care

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Pediatric neuropalliative medicine (PNPM) is a recently developed area of subspecialty neurology practice focused on supporting the complex emotional, psychological, and physical aspects of caring for a child with serious neurological disease.
Lauren Treat, Lori Silveira, Kevin C. Ess   +2 more
wiley   +1 more source