Results 141 to 150 of about 119,873 (307)

Non‐Nutritive Artificial Sweeteners Aspartame and Acesulfame‐K Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease in Male Ldlr−/− Mice

iNew Medicine, EarlyView.
ABSTRACT Aspartame and acesulfame‐K are commonly used non‐nutritive artificial sweeteners, but their impacts on cardiovascular disease and metabolic dysfunction‐associated fatty liver disease (MASLD) are unclear. In this study, we evaluated the impacts of aspartame and acesulfame‐K on MASLD and atherosclerosis in male Ldlr−/− mice fed an AMLN diet ...
Jingjing Xu, Xiaohua Jiang, Jianping Weng, Suowen Xu   +3 more
wiley   +1 more source

Development and validation of a predictive model for hypothalamic obesity following craniopharyngioma resection

BMC Endocrine Disorders
Objective To analyze the risk factors for hypothalamic obesity (HO) after craniopharyngioma surgery, construct a predictive model and verify its efficacy.
Qianshuai Li, Linlin Zhao, Fengjuan Huang, Xuyang Gong, Mengxing Pan, Xinjing Liu, Tianfang Wang, Xulong Li, Yijing Xie, Ankang Gao, Yong Zhang, Yanyan Zhao   +11 more
doaj   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Design and Protocol of the Biobank for Metabolic Syndrome Consequences (BMSC): A Prospective Cohort Study in Northwest China

Clinical Epidemiology
Xue Yang,1,2,* Qian Li,1– 3,* Yayi He,1,* Guozhi Yin,4 Meng Li,1 Wenzhi Zhu,2 Xiayue Fan,2 Yi Gong,2 Yawen Wang,5 Wei Qiang,1 Youfa Wang,3,6 Ko Willems van Dijk,7,8 Patrick CN Rensen,2,8 Hui Guo,1 Bingyin Shi,1 Yanan Wang1– 3 ...
Yang X, Li Q, He Y, Yin G, Li M, Zhu W, Fan X, Gong Y, Wang Y, Qiang W, Wang Y, Willems van Dijk K, Rensen PCN, Guo H, Shi B, Wang Y   +15 more
doaj  

Targeting Metabolic Dysregulation in Obesity and Metabolic Syndrome: The Emerging Role of N-Acetylcysteine

Obesity and metabolic syndrome (MetS), growing global health concerns, are closely linked to the development of insulin resistance, type 2 diabetes, steatotic liver disease, and cardiovascular diseases (CVDs).
Dorota Magdalena Radomska-Leśniewska, Marek Kujawa, Ewa Jankowska-Steifer, Justyna Niderla-Bielińska   +3 more
core   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Time for a More Precise and Practical Laboratory Definition of Metainflammation in Obesity-Related Diseases

Background/Objectives: Metainflammation is a chronic low-grade inflammatory state driven by excessive nutrition and obesity. It is associated with adipocyte dysfunction, altered adipokine secretion, and the development of insulin resistance, which ...
Ana V. Pejčić, Miloš N. Milosavljević, Ivica Petrović   +2 more
core   +1 more source

Challenging the Leukocyte‐Centric Model of Innate Immunity: The Emerging Role of Structural Cells in Immune Defense

iNew Medicine, EarlyView.
Structural cells (endothelial, epithelial, neural, and muscle) actively participate in innate immunity as primary responders, challenging the traditional leukocyte‐centric paradigm and opening new therapeutic avenues for precision medicine. ABSTRACT Innate immunity has long been viewed as the domain of circulating mobile immune cells orchestrating ...
Sofya Urvanova, Suowen Xu
wiley   +1 more source