Results 161 to 170 of about 249,281 (299)

Synaptobrevin-2 Containing Extracellular Vesicles Are Rapidly Incorporated Into Mammalian Neurons via a Dynamin-Dependent Pathway. [PDF]

J Neurochem
Hannett V, Vilcaes AA, Hugelier S, Tang Q, Lakadamyali M, Chanaday NL.   +5 more
europepmc   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

GPR81 Regulates MCT1 Membrane Translocation Through a PKA-Dependent Signaling Pathway in Rat Podocytes. [PDF]

Int J Mol Sci
Grochowalska K, Szrejder M, Audzeyenka I, Piwkowska A.   +3 more
europepmc   +1 more source

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Priming Cells with Modulators of Cellular Signaling Ensures Enhanced Selectivity of HSPG-Specific Protein-Drug Conjugate Delivery. [PDF]

J Am Chem Soc
Chorążewska A, Ciura K, Milczarek M, Kłopotowska D, Pomorski A, Więch-Walów A, Łukianowski B, Gajdzis P, Krężel A, Bartoszewski R, Wietrzyk J, Schaefer L, Porębska N, Opaliński Ł.   +13 more
europepmc   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Targeting EGFR Endocytosis and Signaling for Cancer Drug Delivery and Cancer Treatment. [PDF]

Cancers (Basel)
Chen X, Wang Z.
europepmc   +1 more source

Bypassing Heteronuclear MRI: Metal‐Free Organosilicon Nanotracers for Background‐Free Hotspot 1H Imaging on Clinical Hardware

Advanced Science, EarlyView.
Organosilicon micelles enable background‐free molecular magnetic resonance imaging (MRI) while remaining fully compatible with standard proton (1H) hardware. By exploiting a spectrally silent 1H window at ∼0 ppm, the silicone nanotracer allows hotspot detection by 1H chemical‐shift imaging (CSI) without metals or heteronuclei, enabling direct overlay ...
Martin Orsagh, Dominik Havlicek, Andrea Galisova, Ondrej Sedlacek, Daniel Jirak   +4 more
wiley   +1 more source

Planar cell polarity complex internalization is dependent on Celsr1 <i>cis</i>-dimerization. [PDF]

iScience
Latario SG, Saba T, Trejo B, Giang W, Zimmer SE, Devenport D, Stahley SN.   +6 more
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source