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Reframing clathrin-mediated viral entry: evidence standards, context dependence and host-directed vulnerabilities [PDF]
Frontiers in Cellular and Infection MicrobiologyViral entry is the first obligatory step of productive infection and a rational point for host-directed antiviral intervention. This structured narrative review synthesizes evidence from database searches and citation tracking performed up to 18 June ...
Qinying Wang +6 more
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The contribution of endocytic mediators to itch transmission [PDF]
Frontiers in Molecular NeuroscienceIntroductionChronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety, depression, and suicide.
Marcella de A. Ferreira +10 more
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Bacterial dynamin homolog regulates growth phase-dependent c-di-GMP production [PDF]
mBioThe bacterial second messenger bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) governs the transition from motile to sessile lifestyle by suppressing flagellar motility and promoting the synthesis of the extracellular biofilm matrix.
Xuanlin Chen +4 more
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Frontiers in Cell and Developmental Biology, 2022 Dynamin is an endocytic protein that functions in vesicle formation by scission of invaginated membranes. Dynamin maintains the structure of foot processes in glomerular podocytes by directly and indirectly interacting with actin filaments.
Eriko Hamasaki +16 more
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Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin
Biomolecules, 2022 Guanine nucleotides can flip between a North and South conformation in the ribose moiety. To test the enzymatic activity of GTPases bound to nucleotides in the two conformations, we generated methanocarba guanine nucleotides in the North or South ...
Kiran S. Toti +4 more
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Energy and Dynamics of Caveolae Trafficking
Frontiers in Cell and Developmental Biology, 2021 Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including ...
Claudia Matthaeus, Justin W. Taraska
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CryoEM structure of the super-constricted two-start dynamin 1 filament
Nature Communications, 2021 Dynamin mediates the fission of vesicles during endocytosis. Here, the authors report the cryoEM structure of a super-constricted two-start dynamin 1 filament- one of the two known helical forms of dynamin, with insights into the molecular mechanisms of ...
Jiwei Liu +4 more
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Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes. [PDF]
PLoS ONE, 2013 The large GTPase dynamin plays a key role in endocytosis but is also localized at numerous actin rich sites. We investigated dynamin functions at podosomes/invadosomes, actin-based cellular adhesion structures implicated in tissue invasion.
Olivier Destaing +6 more
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Viruses, 2023 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) canonically utilizes clathrin-mediated endocytosis (CME) and several other endocytic mechanisms to invade airway epithelial cells. Endocytic inhibitors, particularly those targeting CME-related
Mohamed Hessien +11 more
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Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
Cells, 2022 Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins.
Chayanika Gundu +7 more
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