Results 41 to 50 of about 41,917 (266)
Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
Cells, 2022 Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins.
Chayanika Gundu +7 more
doaj +1 more source
Scientific Reports, 2017 Dynamin-2 is a ubiquitously expressed GTP-ase that mediates membrane remodeling. Recent findings indicate that dynamin-2 also regulates actin dynamics.
Arlek M. González-Jamett +12 more
doaj +1 more source
Cells, 2021 Oncolytic adenoviruses (oAds) have been evaluated in numerous clinical trials due to their promising attributes as cancer therapeutics. However, the therapeutic efficacy of oAds was limited due to variable coxsackie and adenovirus receptor (CAR ...
Han-Gyu Chang +5 more
doaj +1 more source
Endocytosis gets in tune with action potential bursts
eLife, 2013 Neurons use a calcium-dependent mechanism to optimize the rate at which synaptic vesicles are recycled.
Melissa A Herman, Christian Rosenmund
doaj +1 more source
Myostatin: a Circulating Biomarker Correlating with Disease in Myotubular Myopathy Mice and Patients
Molecular Therapy: Methods & Clinical Development, 2020 Myotubular myopathy, also called X-linked centronuclear myopathy (XL-CNM), is a severe congenital disease targeted for therapeutic trials. To date, biomarkers to monitor disease progression and therapy efficacy are lacking.
Catherine Koch +27 more
doaj +1 more source
Syntaphilin Binds to Dynamin-1 and Inhibits Dynamin-dependent Endocytosis [PDF]
Journal of Biological Chemistry, 2003 Syntaphilin is a brain-specific syntaxin-binding partner first characterized as an inhibitor of SNARE complex formation and neurotransmitter release. Here we show that syntaphilin also binds to dynamin-1 and through this interaction inhibits dynamin-mediated endocytosis. Immunoprecipitation studies from cross-linked rat synaptosomes demonstrate that an
Sunit, Das +2 more
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2017 Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown.
Carolina Martin +12 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2018 The intact synaptic structure is critical for information processing in neural circuits. During synaptic transmission, rapid vesicle exocytosis increases the size of never terminals and endocytosis counteracts the increase. Accumulating evidence suggests
Xuelin Lou
doaj +1 more source
A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling
eLife, 2021 Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface, where they recognize cargos. They sort cargo and deform the membrane into
Sho W Suzuki +5 more
doaj +1 more source
A dog model for centronuclear myopathy carrying the most common DNM2 mutation
Disease Models & Mechanisms, 2022 Mutations in DNM2 cause autosomal dominant centronuclear myopathy (ADCNM), a rare disease characterized by skeletal muscle weakness and structural anomalies of the myofibres, including nuclear centralization and mitochondrial mispositioning.
Johann Böhm +7 more
doaj +1 more source