Results 41 to 50 of about 35,988 (242)
Scientific Reports, 2017 Dynamin-2 is a ubiquitously expressed GTP-ase that mediates membrane remodeling. Recent findings indicate that dynamin-2 also regulates actin dynamics.
Arlek M. González-Jamett +12 more
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Myostatin: a Circulating Biomarker Correlating with Disease in Myotubular Myopathy Mice and Patients
Molecular Therapy: Methods & Clinical Development, 2020 Myotubular myopathy, also called X-linked centronuclear myopathy (XL-CNM), is a severe congenital disease targeted for therapeutic trials. To date, biomarkers to monitor disease progression and therapy efficacy are lacking.
Catherine Koch +27 more
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Syntaphilin Binds to Dynamin-1 and Inhibits Dynamin-dependent Endocytosis [PDF]
Journal of Biological Chemistry, 2003 Syntaphilin is a brain-specific syntaxin-binding partner first characterized as an inhibitor of SNARE complex formation and neurotransmitter release. Here we show that syntaphilin also binds to dynamin-1 and through this interaction inhibits dynamin-mediated endocytosis. Immunoprecipitation studies from cross-linked rat synaptosomes demonstrate that an
Sunit, Das +2 more
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Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms [PDF]
The Journal of Cell Biology, 1998 A role for dynamin in clathrin-mediated endocytosis is now well established. However, mammals express three closely related, tissue-specific dynamin isoforms, each with multiple splice variants. Thus, an important question is whether these isoforms and splice variants function in vesicle formation from distinct intracellular organelles.
Altschuler, Yoram +6 more
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Endocytosis gets in tune with action potential bursts
eLife, 2013 Neurons use a calcium-dependent mechanism to optimize the rate at which synaptic vesicles are recycled.
Melissa A Herman, Christian Rosenmund
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Frontiers in Cellular and Infection Microbiology, 2017 Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown.
Carolina Martin +12 more
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A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling
eLife, 2021 Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface, where they recognize cargos. They sort cargo and deform the membrane into
Sho W Suzuki +5 more
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Frontiers in Cellular Neuroscience, 2018 The intact synaptic structure is critical for information processing in neural circuits. During synaptic transmission, rapid vesicle exocytosis increases the size of never terminals and endocytosis counteracts the increase. Accumulating evidence suggests
Xuelin Lou
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A dog model for centronuclear myopathy carrying the most common DNM2 mutation
Disease Models & Mechanisms, 2022 Mutations in DNM2 cause autosomal dominant centronuclear myopathy (ADCNM), a rare disease characterized by skeletal muscle weakness and structural anomalies of the myofibres, including nuclear centralization and mitochondrial mispositioning.
Johann Böhm +7 more
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Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor
Membranes, 2015 The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
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