Results 31 to 40 of about 41,917 (266)

A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae [PDF]

, 2001
In vivo time-lapse microscopy reveals that the number of peroxisomes in Saccharomyces cerevisiae cells is fairly constant and that a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process.
Marlene van den Berg, Hettema, E.H., Peter Philippsen, Henk F. Tabak, Hoepfner, D., Tabak, H.F., Dominic Hoepfner, Tabak, H. F., Hettema, E. H., Ewald H. Hettema, van den Berg, M., Philippsen, P.   +11 more
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy [PDF]

, 2012
Current knowledge of the structural changes taking place during clathrin-mediated endocytosis is largely based on electron microscopy images of fixed preparations and x-ray crystallography data of purified proteins.
Merrifield, C.J., Taylor, M, Ziyadeh-Isleem, A, Klenerman, D, Pavel Novak, Marc Bitoun, Lab, M.J., Merrifield, CJ, Guicheney, P., Pascale Guicheney, Novak, P, Gorelik, J., Ivan A. Diakonov, Diakonov, I.A., Klenerman, D., Marcus Taylor, Shevchuk, A.I., Andrew I. Shevchuk, Bitoun, M., Azza Ziyadeh-Isleem, Diakonov, IA, Korchev, Y.E., Bitoun, M, Korchev, YE, Taylor, M., Shevchuk, A., David Klenerman, Ziyadeh-Isleem, A., Lab, MJ, Merrifield, C., Gorelik, J, Novak, P., Christien J. Merrifield, Guicheney, P, Max J. Lab, Julia Gorelik, Diakonov, I., Korchev, Y., Yuri E. Korchev, Lab, M., Shevchuk, AI   +40 more
core   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Mechanistic-Based Classification of Endocytosis-Related Inhibitors: Does It Aid in Assigning Drugs against SARS-CoV-2?

Viruses, 2023
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) canonically utilizes clathrin-mediated endocytosis (CME) and several other endocytic mechanisms to invade airway epithelial cells. Endocytic inhibitors, particularly those targeting CME-related
Mohamed Hessien, Thoria Donia, Ashraf A. Tabll, Eiman Adly, Tawfeek H. Abdelhafez, Amany Attia, Samar Sami Alkafaas, Lucija Kuna, Marija Glasnovic, Vesna Cosic, Robert Smolic, Martina Smolic   +11 more
doaj   +1 more source

Dynamin at actin tails [PDF]

Proceedings of the National Academy of Sciences, 2002
Dynamin, the product of the shibire gene of Drosophila, is a GTPase critically required for endocytosis. Some studies have suggested a functional link between dynamin and the actin cytoskeleton.
Eunkyung, Lee, Pietro, De Camilli
openaire   +2 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion [PDF]

, 2009
Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (mammals), respectively.
Stahlberg, Henning, Laura L. Lackner, Suzanne Hoppins, Nunnari, Jodi, Jodi Nunnari, Henning Stahlberg, Dominguez-Ramirez, Lenin, Lenin Dominguez-Ramirez, Hoppins, Suzanne, Lackner, Laura L., Rachel M. DeVay, DeVay, Rachel M.   +11 more
core   +1 more source

Effect of 4 Weeks of Moderate-Intensity Endurance Exercise and Lithium Administration on Blood Glucose Level in STZ-Induced Type 1 Diabetes Mellitus Mice [PDF]

운동과학, 2022
Purpose The purpose of this study was to investigate the effects of short-term endurance exercise and lithium treatment on fasting blood glucose in rats with type 1 diabetes (T1DM).
Su-Ryun Jung
doaj   +1 more source

The crystal structure of dynamin [PDF]

Nature, 2011
Dynamin-related proteins (DRPs) are multi-domain GTPases that function via oligomerization and GTP-dependent conformational changes to play central roles in regulating membrane structure across phylogenetic kingdoms. How DRPs harness self-assembly and GTP-dependent conformational changes to remodel membranes is not understood.
Marijn G J, Ford, Simon, Jenni, Jodi, Nunnari   +2 more
openaire   +2 more sources