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SUSTAINED EXOCYTOSIS AFTER ACTION POTENTIAL-LIKE STIMULATION AT LOW FREQUENCIES IN MOUSE CHROMAFFIN CELLS DEPENDS ON A DYNAMIN-DEPENDENT FAST ENDOCYTOTIC PROCESS [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2016
Under basal conditions the action potential firing rate of adrenal chromaffin cells is lower than 0.5 Hz. The maintenance of the secretory response at such frequencies requires a continuous replenishment of releasable vesicles.
José Moya-Díaz   +7 more
doaj   +3 more sources

Dynamin and Cytokinesis [PDF]

open access: yesTraffic, 2006
Animal and plant cytokineses appear morphologically distinct. Recent studies, however, have revealed that these cellular processes have many things in common, including the requirement of co‐ordinated membrane trafficking and cytoskeletal dynamics. At the intersection of these two processes are the members of the dynamin family of ubiquitous eukaryotic
Catherine A, Konopka   +3 more
openaire   +2 more sources

The dynamin superfamily [PDF]

open access: yesCurrent Biology, 2018
The dynamin superfamily comprises a growing assortment of multi-domain GTPases, found from bacteria to man, that are distinguished from typical GTPases of the Ras, Rab and G-protein families by their modular structure (Figure 1), relatively large size (>70 kDa), and low affinity for guanine nucleotides.
Rajesh, Ramachandran, Sandra L, Schmid
openaire   +2 more sources

Energy and Dynamics of Caveolae Trafficking

open access: yesFrontiers in Cell and Developmental Biology, 2021
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including ...
Claudia Matthaeus, Justin W. Taraska
doaj   +1 more source

Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]

open access: yes, 1993
The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna   +5 more
core   +3 more sources

Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

open access: yeseLife, 2017
Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and catalyzes membrane fission (Schmid and Frolov, 2011; Ferguson and De Camilli, 2012).
Valentina Galli   +5 more
doaj   +1 more source

Cytoplasmic sharing through apical membrane remodeling

open access: yeseLife, 2020
Multiple nuclei sharing a common cytoplasm are found in diverse tissues, organisms, and diseases. Yet, multinucleation remains a poorly understood biological property. Cytoplasm sharing invariably involves plasma membrane breaches.
Nora G Peterson   +5 more
doaj   +1 more source

Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes. [PDF]

open access: yesPLoS ONE, 2013
The large GTPase dynamin plays a key role in endocytosis but is also localized at numerous actin rich sites. We investigated dynamin functions at podosomes/invadosomes, actin-based cellular adhesion structures implicated in tissue invasion.
Olivier Destaing   +6 more
doaj   +1 more source

Dynamin as a Mover and Pincher during Cell Migration and Invasion [PDF]

open access: yes, 2006
The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell ...
Kruchten, Anne E., McNiven, Mark A.
core   +2 more sources

Dynamin 1 is required for memory formation. [PDF]

open access: yesPLoS ONE, 2014
Dynamin 1-3 isoforms are known to be involved in endocytotic processes occurring during synaptic transmission. No data has directly linked dynamins yet with normal animal behavior.
Mauro Fà   +4 more
doaj   +1 more source

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