Results 51 to 60 of about 41,917 (266)

Targeting Dynamin 2 as a Novel Pathway to Inhibit Cardiomyocyte Apoptosis Following Oxidative Stress

Cellular Physiology and Biochemistry, 2016
Background/Aims: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury.
Danchen Gao, Jian Yang, Yutao Wu, Qiwen Wang, Qiaoling Wang, En Yin Lai, Jianhua Zhu   +6 more
doaj   +1 more source

DNM2 levels normalization improves muscle phenotypes of a novel mouse model for moderate centronuclear myopathy

Molecular Therapy: Nucleic Acids, 2023
Dynamin 2 (DNM2) is a ubiquitously expressed GTPase regulating membrane trafficking and cytoskeleton dynamics. Heterozygous dominant mutations in DNM2 cause centronuclear myopathy (CNM), associated with muscle weakness and atrophy and histopathological ...
Juliana de Carvalho Neves, Foteini Moschovaki-Filippidou, Johann Böhm, Jocelyn Laporte   +3 more
doaj   +1 more source

Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor

Membranes, 2015
The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
doaj   +1 more source

Role of Clathrin and Dynamin in Clathrin Mediated Endocytosis/Synaptic Vesicle Recycling and Implications in Neurological Diseases

Frontiers in Cellular Neuroscience, 2022
Endocytosis is a process essential to the health and well-being of cell. It is required for the internalisation and sorting of “cargo”—the macromolecules, proteins, receptors and lipids of cell signalling.
Kate L. Prichard, Nicholas S. O'Brien, Sari R. Murcia, Jennifer R. Baker, Adam McCluskey   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase

Pharmaceuticals, 2020
The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment.
Anna A. Plyasova, Marina V. Pokrovskaya, Olga M. Lisitsyna, Vadim S. Pokrovsky, Svetlana S. Alexandrova, Abdullah Hilal, Nikolay N. Sokolov, Dmitry D. Zhdanov   +7 more
doaj   +1 more source

Ebulin l Is Internalized in Cells by Both Clathrin-Dependent and -Independent Mechanisms and Does Not Require Clathrin or Dynamin for Intoxication

Toxins, 2021
Ebulin l is an A-B toxin, and despite the presence of a B chain, this toxin displays much less toxicity to cells than the potent A-B toxin ricin. Here, we studied the binding, mechanisms of endocytosis, and intracellular pathway followed by ebulin l and ...
Rosario Iglesias, José M. Ferreras, Alicia Llorente, Lucía Citores   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Crystal structure of the dynamin tetramer [PDF]

, 2015
The mechanochemical protein dynamin is the prototype of the dynamin superfamily of large GTPases, which shape and remodel membranes in diverse cellular processes.
Schlegel, J., Eschenburg, S., Roopsee Anand, Volker Haucke, Ketel, K., York Posor, Haucke, V., Katharina Ketel, Anand, R., Branz, K., Reubold, T. F., Oliver Daumke, Susanne Eschenburg, Curth, U., Daumke, O., Frank Noé, Thomas F. Reubold, Ute Curth, Manstein, D.J., Jeanette Schlegel, Nuria Plattner, Katja Faelber, Noé, F., Plattner, N., Faelber, K., Posor, Y., Reubold, T.F., Manstein, D., Dietmar J. Manstein   +28 more
core   +1 more source

FtsZ-less prokaryotic cell division as well as FtsZ- and dynamin-less chloroplast and non-photosynthetic plastid division

Frontiers in Plant Science, 2014
The chloroplast division machinery is a mixture of a stromal FtsZ-based complex descended from a cyanobacterial ancestor of chloroplasts and a cytosolic dynamin-related protein (DRP) 5B-based complex derived from the eukaryotic host.
Shin-Ya eMiyagishima
doaj   +1 more source