Results 201 to 210 of about 342,266 (343)

Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

open access: yesAdvanced Science, EarlyView.
This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis   +7 more
wiley   +1 more source

Clathrin couture: Fashioning distinctive membrane coats at the cell surface [PDF]

open access: yes, 2009
B. M Collins   +41 more
core   +4 more sources

Designing Tunable DNA Condensates to Control Membrane Budding Transformation in Synthetic Cells

open access: yesAdvanced Science, EarlyView.
In giant unilamellar vesicles (GUVs), membrane wetting of encapsulated liquid‐liquid phase‐separated DNA condensates can be precisely triggered post‐fabrication using photoactivatable DNA‐lipid linkers. On free‐standing membranes, interactions between DNA condensates and the membrane lead to outward budding, resembling exocytosis.
Nastasja Kaletta   +3 more
wiley   +1 more source

Understanding ultrasound induced sonoporation: definitions and underlying mechanisms [PDF]

open access: yes, 2014
De Cock, Ine   +4 more
core   +2 more sources

Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion

open access: yesAdvanced Science, EarlyView.
This study identifies Globo H ceramide (GHCer) as a novel immune checkpoint molecule that suppresses the activation of conventional T lymphocytes while promoting the differentiation and function of regulatory T cells. The immunosuppressive effects of GHCer are mediated through the activation of the A2AR/cAMP/PKA pathway, which involves its interactions
Jing‐Yan Cheng   +13 more
wiley   +1 more source

TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation. [PDF]

open access: yesEMBO Rep
Schultz TE   +12 more
europepmc   +1 more source

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